Literature DB >> 11821534

From funny current to HCN channels: 20 years of excitation.

E A Accili1, C Proenza, M Baruscotti, D DiFrancesco.   

Abstract

The "funny" (pacemaker) current has unusual characteristics, including activation on hyperpolarization, permeability to K(+) and Na(+), modulation by internal cAMP, and a tiny, single-channel conductance. In cardiac cells and neurons, pacemaker channels control repetitive activity and excitability. The recent cloning of HCN subunits provides new insight into the molecular basis for the funny channel properties.

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Year:  2002        PMID： 11821534     DOI： 10.1152/physiologyonline.2002.17.1.32

Source DB:  PubMed          Journal:  News Physiol Sci        ISSN： 0886-1714


  63 in total

1.  Functional expression of the hyperpolarization-activated, non-selective cation current I(f) in immortalized HL-1 cardiomyocytes.

Authors:  Laura Sartiani; Pascal Bochet; Elisabetta Cerbai; Alessandro Mugelli; Rodolphe Fischmeister
Journal:  J Physiol       Date:  2002-11-15       Impact factor: 5.182

2.  Functional impact of the hyperpolarization-activated current on the excitability of myelinated A-type vagal afferent neurons in the rat.

Authors:  Yu-Hong Zhou; Li-Hua Sun; Zhen-Hong Liu; Guixue Bu; Xiao-Ping Pang; Shi-Chao Sun; Guo-Fen Qiao; Bai-Yan Li; John H Schild
Journal:  Clin Exp Pharmacol Physiol       Date:  2010-04-26       Impact factor: 2.557

3.  Expression of the hyperpolarization-activated cyclic nucleotide-gated cation channel HCN4 during mouse heart development.

Authors:  Cristina Garcia-Frigola; Yunqing Shi; Sylvia M Evans
Journal:  Gene Expr Patterns       Date:  2003-12       Impact factor: 1.224

Review 4.  Muscarinic regulation of cardiac ion channels.

Authors:  Robert D Harvey; Andriy E Belevych
Journal:  Br J Pharmacol       Date:  2003-07       Impact factor: 8.739

Review 5.  Regulation of recombinant and native hyperpolarization-activated cation channels.

Authors:  Samuel G A Frère; Mira Kuisle; Anita Lüthi
Journal:  Mol Neurobiol       Date:  2004-12       Impact factor: 5.590

6.  Initiation of embryonic cardiac pacemaker activity by inositol 1,4,5-trisphosphate-dependent calcium signaling.

Authors:  Annabelle Méry; Franck Aimond; Claudine Ménard; Katsuhiko Mikoshiba; Marek Michalak; Michel Pucéat
Journal:  Mol Biol Cell       Date:  2005-03-09       Impact factor: 4.138

7.  The carboxyl-terminal region of cyclic nucleotide-modulated channels is a gating ring, not a permeation path.

Authors:  J P Johnson; William N Zagotta
Journal:  Proc Natl Acad Sci U S A       Date:  2005-02-14       Impact factor: 11.205

8.  Salt bridges and gating in the COOH-terminal region of HCN2 and CNGA1 channels.

Authors:  Kimberley B Craven; William N Zagotta
Journal:  J Gen Physiol       Date:  2004-12       Impact factor: 4.086

9.  Regional distribution of hyperpolarization-activated current (If) and hyperpolarization-activated cyclic nucleotide-gated channel mRNA expression in ventricular cells from control and hypertrophied rat hearts.

Authors:  María Fernández-Velasco; Nora Goren; Gemma Benito; Javier Blanco-Rivero; Lisardo Boscá; Carmen Delgado
Journal:  J Physiol       Date:  2003-09-26       Impact factor: 5.182

10.  Tramadol-induced block of hyperpolarization-activated cation current in rat pituitary lactotrophs.

Authors:  Yen-Chin Liu; Ya-Jean Wang; Pei-Yu Wu; Sheng-Nan Wu
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2008-09-26       Impact factor: 3.000
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