Avner Hershlag1, Michael W Schuster. 1. Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, North Shore University Hospital-New York University School of Medicine, 300 Community Drive, Manhasset, NY 11030, USA. ahershlag@nshs.edu
Abstract
OBJECTIVE: To study cases where bone marrow transplantation (BMT) or peripheral blood stem cell transplantation (PBSCT)-induced menopause was entirely reversed. DESIGN: Retrospective analysis. SETTING: An inpatient BMT unit and an ambulatory fertility center in a university hospital. PATIENT(S): Two patients with Hodgkin's disease and two with advanced breast carcinoma requiring stem cell transplantation. INTERVENTION(S): Estrogen treatment, monitoring of follicle-stimulating hormone (FSH) and estradiol (E(2)) levels, and, ultimately, monitoring of pregnancy. MAIN OUTCOME MEASURE(S): Pregnancy. RESULT(S): All four patients established pregnancies, but two of them elected to terminate due to the use of tamoxifen early in pregnancy. CONCLUSION(S): Menopausal changes resulting from BMT may spontaneously reverse, with reestablishment of normal hormonal function and viable pregnancies.
OBJECTIVE: To study cases where bone marrow transplantation (BMT) or peripheral blood stem cell transplantation (PBSCT)-induced menopause was entirely reversed. DESIGN: Retrospective analysis. SETTING: An inpatient BMT unit and an ambulatory fertility center in a university hospital. PATIENT(S): Two patients with Hodgkin's disease and two with advanced breast carcinoma requiring stem cell transplantation. INTERVENTION(S): Estrogen treatment, monitoring of follicle-stimulating hormone (FSH) and estradiol (E(2)) levels, and, ultimately, monitoring of pregnancy. MAIN OUTCOME MEASURE(S): Pregnancy. RESULT(S): All four patients established pregnancies, but two of them elected to terminate due to the use of tamoxifen early in pregnancy. CONCLUSION(S): Menopausal changes resulting from BMT may spontaneously reverse, with reestablishment of normal hormonal function and viable pregnancies.
Authors: Alexander Rühle; Ramon Lopez Perez; Bingwen Zou; Anca-Ligia Grosu; Peter E Huber; Nils H Nicolay Journal: Stem Cell Rev Rep Date: 2019-06 Impact factor: 5.739
Authors: Tracy N Hadnott; Shaylyn S Stark; Alexa Medica; Andrew C Dietz; Maria Elena Martinez; Brian W Whitcomb; H Irene Su Journal: Fertil Steril Date: 2019-04 Impact factor: 7.329