Literature DB >> 11821057

Conversion of L-tryptophan to serotonin and melatonin in human melanoma cells.

Andrzej Slominski1, Igor Semak, Alexander Pisarchik, Trevor Sweatman, Andre Szczesniewski, Jacobo Wortsman.   

Abstract

We showed in human melanoma cells tryptophan hydroxylase (TPH) and hydroxyindole methyltransferase genes expression with the sequential enzymatic activities of TPH, serotonin (Ser) N-acetyltransferase and hydroxyindole methyltransferase. The presence of the products Ser, 5OH-tryptophan, N-acetylserotonin, melatonin (Mel), 5-methoxytryptamine and 5-methoxytryptophol was documented by liquid chromatography-mass spectrometry. Thus, human melanoma cells can synthesize and metabolize Ser and Mel.

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Year:  2002        PMID： 11821057     DOI： 10.1016/s0014-5793(01)03319-1

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  50 in total

Review 1.  Neuroendocrine system of the skin.

Authors:  Andrzej Slominski
Journal:  Dermatology       Date:  2005       Impact factor: 5.366

Review 2.  Melanocyte receptors: clinical implications and therapeutic relevance.

Authors:  J Andrew Carlson; Gerald P Linette; Andrew Aplin; Bernard Ng; Andrzej Slominski
Journal:  Dermatol Clin       Date:  2007-10       Impact factor: 3.478

3.  5-HT receptors as novel targets for optimizing pigmentary responses in dorsal skin melanophores of frog, Hoplobatrachus tigerinus.

Authors:  Sharique A Ali; Saima Salim; Tarandeep Sahni; Jaya Peter; Ayesha S Ali
Journal:  Br J Pharmacol       Date:  2012-03       Impact factor: 8.739

4.  Neuroendocrinology of the skin: An overview and selective analysis.

Authors:  Michal A Zmijewski; Andrzej T Slominski
Journal:  Dermatoendocrinol       Date:  2011-01

Review 5.  Melatonin, mitochondria, and the skin.

Authors:  Andrzej T Slominski; Michal A Zmijewski; Igor Semak; Tae-Kang Kim; Zorica Janjetovic; Radomir M Slominski; Jaroslaw W Zmijewski
Journal:  Cell Mol Life Sci       Date:  2017-08-12       Impact factor: 9.261

6.  Metabolism of melatonin and biological activity of intermediates of melatoninergic pathway in human skin cells.

Authors:  Tae-Kang Kim; Konrad Kleszczynski; Zorica Janjetovic; Trevor Sweatman; Zongtao Lin; Wei Li; Russel J Reiter; Tobias W Fischer; Andrzej T Slominski
Journal:  FASEB J       Date:  2013-04-25       Impact factor: 5.191

7.  Characterization of serotonin and N-acetylserotonin systems in the human epidermis and skin cells.

Authors:  Andrzej T Slominski; Tae-Kang Kim; Konrad Kleszczyński; Igor Semak; Zorica Janjetovic; Trevor Sweatman; Cezary Skobowiat; Jeffery D Steketee; Zongtao Lin; Arnold Postlethwaite; Wei Li; Russel J Reiter; Desmond J Tobin
Journal:  J Pineal Res       Date:  2019-12-20       Impact factor: 13.007

Review 8.  Melatonin: A Cutaneous Perspective on its Production, Metabolism, and Functions.

Authors:  Andrzej T Slominski; Ruediger Hardeland; Michal A Zmijewski; Radomir M Slominski; Russel J Reiter; Ralf Paus
Journal:  J Invest Dermatol       Date:  2018-02-07       Impact factor: 8.551

Review 9.  Extrapineal melatonin: sources, regulation, and potential functions.

Authors:  Darío Acuña-Castroviejo; Germaine Escames; Carmen Venegas; María E Díaz-Casado; Elena Lima-Cabello; Luis C López; Sergio Rosales-Corral; Dun-Xian Tan; Russel J Reiter
Journal:  Cell Mol Life Sci       Date:  2014-02-20       Impact factor: 9.261

10.  The melatonin-producing system is fully functional in retinal pigment epithelium (ARPE-19).

Authors:  Michał A Zmijewski; Trevor W Sweatman; Andrzej T Slominski
Journal:  Mol Cell Endocrinol       Date:  2009-05-03       Impact factor: 4.102
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