Literature DB >> 11820904

The first intermolecular Friedel-Crafts acylation with beta-lactams.

Kevin W Anderson1, Jetze J Tepe.   

Abstract

The first intermolecular Friedel-Crafts acylation of a variety of aromatic substrates with azetidinones is described. The Friedel-Crafts acylations are performed under very mild conditions, using trifluoromethanesulfonic acid to produce beta-amino aromatic ketones in excellent yields.

Entities:  

Year:  2002        PMID： 11820904     DOI： 10.1021/ol010291w

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

1.  Friedel-Crafts acylation with amides.

Authors:  Erum K Raja; Daniel J DeSchepper; Sten O Nilsson Lill; Douglas A Klumpp
Journal:  J Org Chem       Date:  2012-06-21       Impact factor: 4.354

2.  Formation of acridones by ethylene extrusion in the reaction of arynes with β-lactams and dihydroquinolinones.

Authors:  Yuesi Fang; Donald C Rogness; Richard C Larock; Feng Shi
Journal:  J Org Chem       Date:  2012-07-10       Impact factor: 4.354

3.  Optimization of 4-(N-cycloamino)phenylquinazolines as a novel class of tubulin-polymerization inhibitors targeting the colchicine site.

Authors:  Xiao-Feng Wang; Fang Guan; Emika Ohkoshi; Wanjun Guo; Lili Wang; Dong-Qing Zhu; Sheng-Biao Wang; Li-Ting Wang; Ernest Hamel; Dexuan Yang; Linna Li; Keduo Qian; Susan L Morris-Natschke; Shoujun Yuan; Kuo-Hsiung Lee; Lan Xie
Journal:  J Med Chem       Date:  2014-02-06       Impact factor: 7.446

Review 4.  Recent syntheses of 1,2,3,4-tetrahydroquinolines, 2,3-dihydro-4(1H)-quinolinones and 4(1H)-quinolinones using domino reactions.

Authors:  Baskar Nammalwar; Richard A Bunce
Journal:  Molecules       Date:  2013-12-24       Impact factor: 4.411
  4 in total

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