Literature DB >> 1182086

Treatment of solar keratoses of the extremities with retinoic acid and 5-fluorouracil.

T A Robinson, A M Kligman.   

Abstract

In contrast to solar keratoses of the face, twice daily application of 5% 5-fluorouracil cream was found to be incapable of destroying such lesions situated on the forearms and hands. Twice daily application of 0-1% retinoic acid was also ineffective. Combined use of these agents eradicated keratoses in all twenty subjects with numerous keratoses of the forearms; in only two was the treatment ineffective for keratoses of the hands.

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Year:  1975        PMID: 1182086     DOI: 10.1111/j.1365-2133.1975.tb03153.x

Source DB:  PubMed          Journal:  Br J Dermatol        ISSN: 0007-0963            Impact factor:   9.302


  3 in total

1.  Transdermal delivery of 5-fluorouracil through skin of hairless mice and humans in vitro: a comparison of the effect of formulations and a prodrug.

Authors:  E F Sherertz; K B Sloan; R G McTiernan
Journal:  Arch Dermatol Res       Date:  1990       Impact factor: 3.017

2.  Lack of enhancement of experimental photocarcinogenesis by topical retinoic acid.

Authors:  L H Kligman; A M Kligman
Journal:  Arch Dermatol Res       Date:  1981       Impact factor: 3.017

Review 3.  Tretinoin. A review of its pharmacological properties and clinical efficacy in the topical treatment of photodamaged skin.

Authors:  S Noble; A J Wagstaff
Journal:  Drugs Aging       Date:  1995-06       Impact factor: 3.923

  3 in total

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