AIM:To study the angiogenesis induced by liver cancer with different metastatic potentials using corneal micropocket model in nude mice. METHODS: Corneal micropockets were created in nude mice. Tumor tissues and liver tissues were implanted into the corneal micropockets. Angiogenesis was observed usinga digital camera under slit-lamp biomicroscope,and compared among different grafts and incision alone. Vascular responses were recorded in regard to the range, number and length of new blood vessels toward the grafts or incisions. RESULTS: Vascular responses induced by tumor tissues were greater than those by incision alone and liver tissue grafts. LCI-D20 induced more intensive angiogenesis than LCI-D35. CONCLUSION: Highly metastatic liver cancer LCI D20 was more angiogenic than low metastatic cancer LCI D35 and liver tissue. Micropocket was a useful model to study dynamic process of angiogenesis in vivo.
AIM:To study the angiogenesis induced by liver cancer with different metastatic potentials using corneal micropocket model in nude mice. METHODS: Corneal micropockets were created in nude mice. Tumor tissues and liver tissues were implanted into the corneal micropockets. Angiogenesis was observed usinga digital camera under slit-lamp biomicroscope,and compared among different grafts and incision alone. Vascular responses were recorded in regard to the range, number and length of new blood vessels toward the grafts or incisions. RESULTS: Vascular responses induced by tumor tissues were greater than those by incision alone and liver tissue grafts. LCI-D20 induced more intensive angiogenesis than LCI-D35. CONCLUSION: Highly metastatic liver cancer LCI D20 was more angiogenic than low metastatic cancer LCI D35 and liver tissue. Micropocket was a useful model to study dynamic process of angiogenesis in vivo.
Authors: Yang Xu; Hui-Chuan Sun; Bo Tian; Yan Li; Jie Chen; Jun Chen; Dong-Mei Gao; Qiong Xue; Zhao-You Tang Journal: J Cancer Res Clin Oncol Date: 2004-07 Impact factor: 4.553
Authors: Z Y Tang; F X Sun; J Tian; S L Ye; Y K Liu; K D Liu; Q Xue; J Chen; J L Xia; L X Qin; S L Sun; L Wang; J Zhou; Y Li; Z C Ma; X D Zhou; Z Q Wu; Z Y Lin; B H Yang Journal: World J Gastroenterol Date: 2001-10 Impact factor: 5.742