Literature DB >> 11819355

In situ hybridization assay of androgen receptor gene in hepatocarcinogenesis.

Guo-Qiang Zhao, Ling Xue, Hong-Yu Xu, Xi-Ming Tang, Rui-De Hu, Jun Dong.   

Abstract

AIM:To determine the correlation between expression of androgen receptor (AR) gene and hepatocarcinogenesis.
METHODS: Male SD rats were used as experimental animals and the animal model of experimental hepatocarcinoma was established by means of 3'-me-DAB administration. Androgen receptor mRNA was detected by a non-radioactive in situ hybridization assay in neoplastic and non-neoplastic liver tissues.
RESULTS: The expression of androgen receptor mRNA was observed only in neoplastic cells and some atypical hyperplastic cells. In the liver tissue of control animal and the remaining normal liver cells adjacent to the carcinoma tissue, no positive signal was seen.
CONCLUSION: Androgen has an important correlation with hepatocarcinogenesis and the expression of androgen receptor gene might be a mark event during hepatocarcinogenesis.

Entities:  

Year:  1998        PMID： 11819355      PMCID： PMC4723438          DOI： 10.3748/wjg.v4.i6.503

Source DB:  PubMed          Journal:  World J Gastroenterol        ISSN： 1007-9327            Impact factor:   5.742


  3 in total

Review 1.  Growth factors, endocrine aspects and hormonal treatment in hepatocellular carcinoma--an overview.

Authors:  C N d'Arville; P J Johnson
Journal:  J Steroid Biochem Mol Biol       Date:  1990-12-20       Impact factor: 4.292

2.  Oral-contraceptive-induced benign liver tumors--the magnitude of the problem.

Authors:  H Jick; R Herman
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3.  Expression of steroid hormone receptors in benign hepatic tumors. An immunocytochemical study.

Authors:  S Masood; A B West; K W Barwick
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  3 in total
  5 in total

1.  Differentially expressed genes in hepatocellular carcinoma induced by woodchuck hepatitis B virus in mice.

Authors:  X Y Cao; J Liu; Z R Lian; M Clayton; J L Hu; M H Zhu; D M Fan; M Feitelson
Journal:  World J Gastroenterol       Date:  2001-08       Impact factor: 5.742

2.  Cloning of differentially expressed genes in human hepatocellular carcinoma and nontumor liver.

Authors:  X Y Cao; J Liu; Z R Lian; M Clayton; J L Hu; M H Zhu; D M Fan; M Feitelson
Journal:  World J Gastroenterol       Date:  2001-08       Impact factor: 5.742

3.  Methodologic research on TIMP-1, TIMP-2 detection as a new diagnostic index for hepatic fibrosis and its significance.

Authors:  Qing-He Nie; Yong-Qian Cheng; Yu-Mei Xie; Yong-Xing Zhou; Xian-Guang Bai; Yi-Zhan Cao
Journal:  World J Gastroenterol       Date:  2002-04       Impact factor: 5.742

4.  Angiogenesis effect on rat liver after administration of expression vector encoding vascular endothelial growth factor D.

Authors:  Bao-Min Shi; Xiu-Yan Wang; Qing-Ling Mu; Tai-Huang Wu; Hong-Jun Liu; Zhen Yang
Journal:  World J Gastroenterol       Date:  2003-02       Impact factor: 5.742

5.  A selective tropism of transfused oval cells for liver.

Authors:  Jian-Zhi Chen; Hai Hong; Jin Xiang; Ling Xue; Guo-Qiang Zhao
Journal:  World J Gastroenterol       Date:  2003-03       Impact factor: 5.742
  5 in total

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