AIM:To evaluate the killing effects of CDDP, 5-Fu and VCR on human hepaoma cell line (7721). METHODS: The median-effect principle was used. RESULTS: Killing effects of the individual drug were enhanced as the median concentration increased. Antagonism was produced when two drugs were used at a higher concentration (CI > 1), and synergism was achiened when CI < 1. Finally, the effect was influenced by both the ratios of drug concentration and the sequence of administration. CONCLUSION: The drug administration order and drug concentrations are significant factors that need to be considered in clinical practice.
AIM:To evaluate the killing effects of CDDP, 5-Fu and VCR on human hepaoma cell line (7721). METHODS: The median-effect principle was used. RESULTS: Killing effects of the individual drug were enhanced as the median concentration increased. Antagonism was produced when two drugs were used at a higher concentration (CI > 1), and synergism was achiened when CI < 1. Finally, the effect was influenced by both the ratios of drug concentration and the sequence of administration. CONCLUSION: The drug administration order and drug concentrations are significant factors that need to be considered in clinical practice.
Authors: H P Hofs; D J Wagener; V de Valk-Bakker; H van Rennes; H C Ottenheijm; W J de Grip Journal: Anticancer Drugs Date: 1994-02 Impact factor: 2.248
Authors: T T Chang; S C Gulati; T C Chou; R Vega; L Gandola; S M Ibrahim; J Yopp; M Colvin; B D Clarkson Journal: Cancer Res Date: 1985-06 Impact factor: 12.701
Authors: Jordan S Taylor; Burcin Yavuz; Jasmine Zeki; Lauren Wood; Naohiko Ikegaki; Jeannine Coburn; Kristin Harrington; Hiroyuki Shimada; David L Kaplan; Bill Chiu Journal: Surgery Date: 2020-02-28 Impact factor: 3.982