Literature DB >> 11819308

Reversing effect of Tanshinone on malignant phenotypes of human hepatocarcinoma cell line.

Shu-Lan Yuan, Ren-Min Huang, Xiu-Jie Wang, Yi Song, Guang-Qi Huang.   

Abstract

AIM:To study the reversing effect of Chinese drug tanshinone on malignant phenotype of cancer cells.
METHODS: Human hepatocarcinoma cell line (SMMC-7721) was treated in vitro with 0.5mg/L tanshinone for 4 days, and variation in cell differentiation wasdetected.
RESULTS: The morphology of cancer cells was tended toward well differentiation and cell growth was markedly inhibited. BrdU uptake assay and immunohistochemical stain of PCNA showed that the BrdU labeling rate and PCNA positive rate were lower than the controls, but no difference was found statistically as compared with all transretinoic acid.Flow cytometric assay demonstrated that S phase cells decreased and G(0)/G(1) phase cells increased. Expression of c-myc oncogene protein decreased but the c-fos oncogene protein markedly increased.
CONCLUSION: Tanshinone could reverse the inducing differentiation in human hepatocarcinoma cells (SMMC-7721). It may become a new prospective inducer of cell differentiation to treat cancers.

Entities:  

Year:  1998        PMID： 11819308      PMCID： PMC4761549          DOI： 10.3748/wjg.v4.i4.317

Source DB:  PubMed          Journal:  World J Gastroenterol        ISSN： 1007-9327            Impact factor:   5.742


  6 in total

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2.  Cytotoxic activities of tanshinones against human carcinoma cell lines.

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3.  [Reversing effect of retinoic acid on some phenotypes of human hepatocarcinoma cell line].

Authors:  Z W Ai
Journal:  Zhonghua Zhong Liu Za Zhi       Date:  1991-01

4.  Morphological and clinical significance of cell kinetics in non-Hodgkin's lymphomas.

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Journal:  Basic Appl Histochem       Date:  1986

5.  Cyclin/PCNA is the auxiliary protein of DNA polymerase-delta.

Authors:  R Bravo; R Frank; P A Blundell; H Macdonald-Bravo
Journal:  Nature       Date:  1987 Apr 2-8       Impact factor: 49.962

6.  Evaluation of proliferating cell nuclear antigen (PCNA) as an endogenous marker of cell proliferation in rat liver: a dual-stain comparison with 5-bromo-2'-deoxyuridine.

Authors:  K M Connolly; M S Bogdanffy
Journal:  J Histochem Cytochem       Date:  1993-01       Impact factor: 2.479
  6 in total
  12 in total

1.  Differentially expressed genes in hepatocellular carcinoma induced by woodchuck hepatitis B virus in mice.

Authors:  X Y Cao; J Liu; Z R Lian; M Clayton; J L Hu; M H Zhu; D M Fan; M Feitelson
Journal:  World J Gastroenterol       Date:  2001-08       Impact factor: 5.742

2.  Effects of tachyplesin on proliferation and differentiation of human hepatocellular carcinoma SMMC-7721 cells.

Authors:  Gao-Liang Ouyang; Qi-Fu Li; Xuan-Xian Peng; Qing-Rong Liu; Shui-Gen Hong
Journal:  World J Gastroenterol       Date:  2002-12       Impact factor: 5.742

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4.  Residual hepatocellular carcinoma after oxaliplatin treatment has increased metastatic potential in a nude mouse model and is attenuated by Songyou Yin.

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Journal:  BMC Cancer       Date:  2010-05-20       Impact factor: 4.430

5.  Herbal extract "Songyou Yin" inhibits tumor growth and prolongs survival in nude mice bearing human hepatocellular carcinoma xenograft with high metastatic potential.

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6.  Growth inhibition and apoptosis induction of tanshinone II-A on human hepatocellular carcinoma cells.

Authors:  Shu-Lan Yuan; Yu-Quan Wei; Xiu-Jie Wang; Fei Xiao; Sheng-Fu Li; Jie Zhang
Journal:  World J Gastroenterol       Date:  2004-07-15       Impact factor: 5.742

7.  Inhibitory effects of tanshinone II-A on invasion and metastasis of human colon carcinoma cells.

Authors:  Yun-feng Shan; Xian Shen; Yuan-kang Xie; Ji-cai Chen; Hong-qi Shi; Zheng-ping Yu; Qi-tong Song; Men-tao Zhou; Qi-yu Zhang
Journal:  Acta Pharmacol Sin       Date:  2009-10-12       Impact factor: 6.150

8.  Overexpression of c-fos in Helicobacter pylori-induced gastric precancerosis of Mongolian gerbil.

Authors:  Yong-Li Yang; Bo Xu; Yu-Gang Song; Wan-Dai Zhang
Journal:  World J Gastroenterol       Date:  2003-03       Impact factor: 5.742

9.  Effects of tachyplesin on the regulation of cell cycle in human hepatocarcinoma SMMC-7721 cells.

Authors:  Qi-Fu Li; Gao-Liang Ou-Yang; Xuan-Xian Peng; Shui-Gen Hong
Journal:  World J Gastroenterol       Date:  2003-03       Impact factor: 5.742

10.  Herbal compound "Songyou Yin" attenuates hepatoma cell invasiveness and metastasis through downregulation of cytokines secreted by activated hepatic stellate cells.

Authors:  Qing-An Jia; Zhi-Ming Wang; Zheng-Gang Ren; Yang Bu; Xiao-Ying Xie; Yan-Hong Wang; Lan Zhang; Qiang-Bo Zhang; Tong-Chun Xue; Li-Fen Deng; Zhao-You Tang
Journal:  BMC Complement Altern Med       Date:  2013-04-27       Impact factor: 3.659
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