Literature DB >> 11818235

Biochemical composition, lethality and pathophysiology of venom from two cobras-- Naja naja and N. kaouthia.

A K Mukherjee1, C R Maity.   

Abstract

The cobras Naja naja and N. kaouthia are abundant in eastern and north-eastern India, accounting for maximum snakebite deaths. Here we report on variation in the composition of Naja kaouthia and N. naja venom from eastern India on corresponding differences in the severity of pathogenesis. These two venoms differ in chromatographic elution profile through Sephadex G-50 and enzyme activity, protein and carbohydrate contents associated with each fraction. The presence of greater amounts of basic phospholipase A2, L-amino acid oxidase and low molecular weight membrane active polypeptides in the N. naja venom makes it more toxic than N. kaouthia venom. A commercial polyvalent antivenom raised against N. naja venom inactivates lethality and variety of toxic effects of homologous venom more effectively than N. kaouthia venom.

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Year:  2002        PMID： 11818235     DOI： 10.1016/s1096-4959(01)00473-0

Source DB:  PubMed          Journal:  Comp Biochem Physiol B Biochem Mol Biol        ISSN： 1096-4959            Impact factor:   2.231


  14 in total

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Review 3.  New approaches & technologies of venomics to meet the challenge of human envenoming by snakebites in India.

Authors:  David A Warrell; José Maria Gutiérrez; Juan J Calvete; David Williams
Journal:  Indian J Med Res       Date:  2013       Impact factor: 2.375

4.  Non-covalent interaction of phospholipase A(2) (PLA(2)) and kaouthiotoxin (KTX) from venom of Naja kaouthia exhibits marked synergism to potentiate their cytotoxicity on target cells.

Authors:  Ashis K Mukherjee
Journal:  J Venom Res       Date:  2010-09-30

5.  Early Treatment with Intranasal Neostigmine Reduces Mortality in a Mouse Model of Naja naja (Indian Cobra) Envenomation.

Authors:  Matthew R Lewin; Stephen P Samuel; David S Wexler; Philip Bickler; Sakthivel Vaiyapuri; Brett D Mensh
Journal:  J Trop Med       Date:  2014-05-14

6.  Two acidic, anticoagulant PLA2 isoenzymes purified from the venom of monocled cobra Naja kaouthia exhibit different potency to inhibit thrombin and factor Xa via phospholipids independent, non-enzymatic mechanism.

Authors:  Ashis K Mukherjee; Bhargab Kalita; Rupamoni Thakur
Journal:  PLoS One       Date:  2014-08-13       Impact factor: 3.240

7.  Green medicine as a harmonizing tool to antivenom therapy for the clinical management of snakebite: the road ahead.

Authors:  Ashis K Mukherjee
Journal:  Indian J Med Res       Date:  2012-07       Impact factor: 2.375

8.  Biochemical and biological characterization of Naja kaouthia venom from North-East India and its neutralization by polyvalent antivenom.

Authors:  Diganta Das; Nanjaraj Urs; Vilas Hiremath; Bannikuppe Sannanaik Vishwanath; Robin Doley
Journal:  J Venom Res       Date:  2013-11-06

9.  Antibacterial activity of an acidic phospholipase A2 (NN-XIb-PLA2) from the venom of Naja naja (Indian cobra).

Authors:  S Sudarshan; B L Dhananjaya
Journal:  Springerplus       Date:  2016-02-03

10.  Proteomics and antivenomics of Echis carinatus carinatus venom: Correlation with pharmacological properties and pathophysiology of envenomation.

Authors:  Aparup Patra; Bhargab Kalita; Abhishek Chanda; Ashis K Mukherjee
Journal:  Sci Rep       Date:  2017-12-07       Impact factor: 4.379
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