Literature DB >> 11817718

Growth hormone-inhibiting activity of cortistatin in the rat.

R Deghenghi1, R Avallone, A Torsello, G Muccioli, E Ghigo, V Locatelli.   

Abstract

Cortistatin-14 (CST-14) is an endogenous neuropeptide with notable structural similarities to native somatostatin-14 (SS-14), but different physiological functions. Differences in the physiology of the two peptides do not provide conclusive evidence for a specific receptor for CST. To date, the effects of CST-14 on anterior pituitary hormones have never been reported. Aim of this study was to investigate the in vivo effects of CST-14 on GH secretion in comparison to SS-14. Our results demonstrate that CST-14 was very effective in reducing GH secretion in normal male anaesthetized rats. Its activity was similar to that of SS-14 and had a rapid onset and a slightly longer duration of action. In conclusion, we have reported for the first time that CST is a potent and effective inhibitor of GH release in rats and that its action may be mediated by the interaction with one or different SS receptor subtypes.

Entities:  

Mesh：

Substances：

Year:  2001        PMID： 11817718     DOI： 10.1007/BF03343939

Source DB:  PubMed          Journal:  J Endocrinol Invest        ISSN： 0391-4097            Impact factor:   4.256


  10 in total

Review 1.  Neuroendocrine control of growth hormone secretion.

Authors:  E E Müller; V Locatelli; D Cocchi
Journal:  Physiol Rev       Date:  1999-04       Impact factor: 37.312

2.  Somatostatin octapeptides (lanreotide, octreotide, vapreotide, and their analogs) share the growth hormone-releasing peptide receptor in the human pituitary gland.

Authors:  R Deghenghi; M Papotti; E Ghigo; G Muccioli; V Locatelli
Journal:  Endocrine       Date:  2001-02       Impact factor: 3.633

Review 3.  Molecular biology of somatostatin receptors.

Authors:  G I Bell; T Reisine
Journal:  Trends Neurosci       Date:  1993-01       Impact factor: 13.837

4.  A cortical neuropeptide with neuronal depressant and sleep-modulating properties.

Authors:  L de Lecea; J R Criado; O Prospero-Garcia; K M Gautvik; P Schweitzer; P E Danielson; C L Dunlop; G R Siggins; S J Henriksen; J G Sutcliffe
Journal:  Nature       Date:  1996-05-16       Impact factor: 49.962

5.  Binding of 125I-labeled ghrelin to membranes from human hypothalamus and pituitary gland.

Authors:  G Muccioli; M Papotti; V Locatelli; E Ghigo; R Deghenghi
Journal:  J Endocrinol Invest       Date:  2001-03       Impact factor: 4.256

6.  Cortistatin, but not somatostatin, binds to growth hormone secretagogue (GHS) receptors of human pituitary gland.

Authors:  R Deghenghi; M Papotti; E Ghigo; G Muccioli
Journal:  J Endocrinol Invest       Date:  2001-01       Impact factor: 4.256

7.  Growth hormone secretagogue binding sites in peripheral human tissues.

Authors:  M Papotti; C Ghè; P Cassoni; F Catapano; R Deghenghi; E Ghigo; G Muccioli
Journal:  J Clin Endocrinol Metab       Date:  2000-10       Impact factor: 5.958

Review 8.  Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions.

Authors:  A D Spier; L de Lecea
Journal:  Brain Res Brain Res Rev       Date:  2000-09

9.  [125I]Tyr10-cortistatin14 labels all five somatostatin receptors.

Authors:  S Siehler; K Seuwen; D Hoyer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1998-05       Impact factor: 3.000

Review 10.  Biologic activities of growth hormone secretagogues in humans.

Authors:  E Ghigo; E Arvat; R Giordano; F Broglio; L Gianotti; M Maccario; G Bisi; A Graziani; M Papotti; G Muccioli; R Deghenghi; F Camanni
Journal:  Endocrine       Date:  2001-02       Impact factor: 3.925
  10 in total
  7 in total

1.  Somatostatin analogues: are they analogues of somatostatin?

Authors:  R Deghenghi
Journal:  J Endocrinol Invest       Date:  2002-04       Impact factor: 4.256

2.  Cortistatin is not a somatostatin analogue but stimulates prolactin release and inhibits GH and ACTH in a gender-dependent fashion: potential role of ghrelin.

Authors:  José Córdoba-Chacón; Manuel D Gahete; Ana I Pozo-Salas; Antonio J Martínez-Fuentes; Luis de Lecea; Francisco Gracia-Navarro; Rhonda D Kineman; Justo P Castaño; Raul M Luque
Journal:  Endocrinology       Date:  2011-10-04       Impact factor: 4.736

3.  Effects of cortistatin-14 and somatostatin-14 on the endocrine response to hexarelin in humans.

Authors:  A Benso; C Gottero; F Prodam; C Gauna; S Destefanis; L Filtri; A J van der Lely; R Deghenghi; E Ghigo; F Broglio
Journal:  J Endocrinol Invest       Date:  2003-07       Impact factor: 4.256

4.  Presence of cortistatin in the human pancreas.

Authors:  M Papotti; E Tarabra; E Allia; F Bozzalla-Cassione; F Broglio; R Deghenghi; E Ghigo; G Muccioli
Journal:  J Endocrinol Invest       Date:  2003-08       Impact factor: 4.256

5.  Activation of somatostatin 2 receptors in the brain and the periphery induces opposite changes in circulating ghrelin levels: functional implications.

Authors:  Andreas Stengel; Yvette Taché
Journal:  Front Endocrinol (Lausanne)       Date:  2013-01-11       Impact factor: 5.555

Review 6.  Targeting the ghrelin receptor: orally active GHS and cortistatin analogs.

Authors:  Romano Deghenghi; Fabio Broglio; Mauro Papotti; Giampiero Muccioli; Ezio Ghigo
Journal:  Endocrine       Date:  2003-10       Impact factor: 3.925

7.  Centrally Administered Cortistation-14 Induces Antidepressant-Like Effects in Mice via Mediating Ghrelin and GABAA Receptor Signaling Pathway.

Authors:  JinHong Jiang; YaLi Peng; XueYa Liang; Shu Li; Xin Chang; LongFei Li; Min Chang
Journal:  Front Pharmacol       Date:  2018-07-19       Impact factor: 5.810
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.