[A new in vivo method for the detection of carriers of haemophilia (author's transl)].

We examined 14 carriers of haemophilia A with the "Haemorrhagometer". The cold tolerance test (at 17 degrees C) revealed that 9 out of 10 proven and 3 out of 4 probable carriers had a pathologically prolonged bleeding time. Accordingly blood loss was pathologically elevated in 9 out of 10 proven and 2 out of 4 probable carriers. At room temperature the difference between normal control persons and carriers of haemophilia A was not as pronounced. 5 of 8 proven and 3 of 4 probable carriers showed pathologically elevated bleeding intensity, only 1 of 8 proven and none of 4 probable carriers showed abnormally prolonged bleeding time. Haemorrhagometry at 17 degrees C (cold tolerance test) may be helpful to ascertain whether or not a woman is a carrier of haemophilia A.