Literature DB >> 11814835

Synthesis and antimycobacterial activity of new S-alkylisothiosemicarbazone derivatives.

Maria Teresa Cocco1, Cenzo Congiu, Valentina Onnis, Maria Luisa Pellerano, Alessandro De Logu.   

Abstract

A new series of S-alkylisothiosemicarbazones of 3- and 4-pyridincarboxaldehyde and 4-fluoro- and 4-trifluoromethylbenzaldehyde was synthesized and evaluated for biological activity against various Mycobacterium strains. Inhibitory activity against Mycobacterium tuberculosis H37Rv ATCC 27294 and INH-R ATCC 35822 was compared with activity against clinical isolated Mycobacteria as well as against MOTT. Some of newly prepared compounds showed best inhibitory values against clinical isolated Mycobacteria, besides to low citotoxicity values.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 11814835     DOI： 10.1016/s0968-0896(01)00310-8

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  3 in total

1.  Cytotoxic activities of new iron(III) and nickel(II) chelates of some S-methyl-thiosemicarbazones on K562 and ECV304 cells.

Authors:  Belkis Atasever; Bahri Ulküseven; Tülay Bal-Demirci; Serap Erdem-Kuruca; Zeynep Solakoğlu
Journal:  Invest New Drugs       Date:  2009-06-04       Impact factor: 3.850

2.  Synthesis and Biological Evaluation of Thiosemicarbazide Derivatives Endowed with High Activity toward Mycobacterium Bovis.

Authors:  Soroush Sardari; Samaneh Feizi; Ali Hossein Rezayan; Parisa Azerang; Seyyed Mohammad Shahcheragh; Ghazaleh Ghavami; Azizollah Habibi
Journal:  Iran J Pharm Res       Date:  2017       Impact factor: 1.696

3.  Antimicrobial activity of a series of thiosemicarbazones and their Zn(II) and Pd(II) complexes.

Authors:  I Kizilcikli; Y D Kurt; B Akkurt; A Y Genel; S Birteksöz; G Otük; B Ulküseven
Journal:  Folia Microbiol (Praha)       Date:  2007       Impact factor: 2.629
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.