| Literature DB >> 11814820 |
Gaetan H Ladouceur1, James H Cook, Elizabeth M Doherty, William R Schoen, Margit L MacDougall, James N Livingston.
Abstract
5-Hydroxyalkyl-4-phenylpyridines have been identified as a novel class of glucagon antagonists with potential utility for the treatment of diabetes. A lead structure with moderate activity was discovered through a high throughput screening assay. Structure-activity relationships led to the discovery of a potent antagonist, IC(50)=0.11 microM, more than 60-fold improvement over the lead structure.Entities:
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Year: 2002 PMID： 11814820 DOI： 10.1016/s0960-894x(01)00766-1
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823