Literature DB >> 11814810

Structure-activity relationships for analogues of the phenazine-based dual topoisomerase I/II inhibitor XR11576.

Shouming Wang1, Warren Miller, John Milton, Nigel Vicker, Alistair Stewart, Peter Charlton, Prakash Mistry, David Hardick, William A Denny.   

Abstract

As part of a programme to identify further analogues of the dual topo I/II inhibitor XR11576, we describe here the syntheses and SAR studies of various 'minimal' and 3,4-benzofused phenazine chromophores of the phenazine template of XR11576.

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Year:  2002        PMID： 11814810     DOI： 10.1016/s0960-894x(01)00770-3

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

1.  Discovery of indeno[1, 2 - c] quinoline derivatives as dual topoisomerases I/II inhibitors: part 3.

Authors:  Chih-Hua Tseng; Cherng-Chyi Tzeng; Chiao-Li Yang; Pei-Jung Lu; Yu-Peng Liu; Hui-Ling Chen; Chien-Yu Chen; Chia-Ning Yang; Yeh-Long Chen
Journal:  Mol Divers       Date:  2013-11       Impact factor: 2.943

2.  Molecular docking studies on thirteen fluoroquinolines with human topoisomerase II a and b.

Authors:  Ashwini Khanderao Jadhav; Sankunny Mohan Karuppayil
Journal:  In Silico Pharmacol       Date:  2017-06-30

3.  An efficient and environmentally sustainable domino protocol for the synthesis of structurally diverse spiroannulated pyrimidophenazines using erbium doped TiO2 nanoparticles as a recyclable and reusable heterogeneous acid catalyst.

Authors:  Kanchan Verma; Yogesh Kumar Tailor; Sarita Khandelwal; Monu Agarwal; Esha Rushell; Yogita Kumari; Kamlendra Awasthi; Mahendra Kumar
Journal:  RSC Adv       Date:  2018-08-28       Impact factor: 4.036

Review 4.  Topoisomerase II as a target for repurposed antibiotics in Candida albicans: an in silico study.

Authors:  Ashwini Khanderao Jadhav; Sankunny Mohan Karuppayil
Journal:  In Silico Pharmacol       Date:  2021-03-26

Review 5.  A review on lawsone-based benzo[a]phenazin-5-ol: synthetic approaches and reactions.

Authors:  Abolfazl Olyaei; Mahdieh Sadeghpour
Journal:  RSC Adv       Date:  2022-05-09       Impact factor: 4.036

6.  Structural Recognition and Binding Pattern Analysis of Human Topoisomerase II Alpha with Steroidal Drugs: In Silico Study to Switchover the Cancer Treatment.

Authors:  Qazi Mohammad Sajid Jamal
Journal:  Asian Pac J Cancer Prev       Date:  2020-05-01

7.  Phase I and pharmacokinetic study of XR11576, an oral topoisomerase I and II inhibitor, administered on days 1-5 of a 3-weekly cycle in patients with advanced solid tumours.

Authors:  M J A de Jonge; S Kaye; J Verweij; C Brock; S Reade; M Scurr; L van Doorn; C Verheij; W Loos; C Brindley; P Mistry; M Cooper; I Judson
Journal:  Br J Cancer       Date:  2004-10-18       Impact factor: 7.640

8.  A High-Throughput Screening Method for Determining the Optimized Synthesis Conditions of Quinoxaline Derivatives Using Microdroplet Reaction.

Authors:  Yanmei Yang; Junmin Liu; Zhenzhen Chen; Weihua Niu; Ran Li; Le Niu; Peng Yang; Xiaoyan Mu; Bo Tang
Journal:  Front Chem       Date:  2020-09-10       Impact factor: 5.221

Review 9.  Novel DNA Bis-Intercalator XR5944 as a Potent Anticancer Drug-Design and Mechanism of Action.

Authors:  Adam J Buric; Jonathan Dickerhoff; Danzhou Yang
Journal:  Molecules       Date:  2021-07-07       Impact factor: 4.411
  9 in total

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