Literature DB >> 11814808

[(3)H]-M-MPEP, a potent, subtype-selective radioligand for the metabotropic glutamate receptor subtype 5.

Fabrizio Gasparini1, Hendrik Andres, Peter Josef Flor, Micheline Heinrich, Werner Inderbitzin, Kurt Lingenhöhl, Hanspeter Müller, Veronica Cecilia Munk, Kyla Omilusik, Christine Stierlin, Natacha Stoehr, Ivo Vranesic, Rainer Kuhn.   

Abstract

The synthesis of a new potent, subtype-selective radioligand [(3)H]-M-MPEP (2-methyl-6-((3-methoxyphenyl)ethynyl)-pyridine) and its in vitro pharmacological characteristics are described. Science Ltd.

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Year:  2002        PMID： 11814808     DOI： 10.1016/s0960-894x(01)00767-3

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  14 in total

1.  In vivo positron emission tomography imaging with [¹¹C]ABP688: binding variability and specificity for the metabotropic glutamate receptor subtype 5 in baboons.

Authors:  Christine DeLorenzo; Matthew S Milak; Kathleen G Brennan; J S Dileep Kumar; J John Mann; Ramin V Parsey
Journal:  Eur J Nucl Med Mol Imaging       Date:  2011-01-29       Impact factor: 9.236

Review 2.  Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors.

Authors:  Craig W Lindsley; Kyle A Emmitte; Corey R Hopkins; Thomas M Bridges; Karen J Gregory; Colleen M Niswender; P Jeffrey Conn
Journal:  Chem Rev       Date:  2016-02-16       Impact factor: 60.622

3.  Metabotropic glutamate receptor mGluR5 is not involved in the early hemodynamic response.

Authors:  Novella Calcinaghi; Renaud Jolivet; Matthias T Wyss; Simon M Ametamey; Fabrizio Gasparini; Alfred Buck; Bruno Weber
Journal:  J Cereb Blood Flow Metab       Date:  2011-07-06       Impact factor: 6.200

4.  Molecular Insights into Metabotropic Glutamate Receptor Allosteric Modulation.

Authors:  Karen J Gregory; P Jeffrey Conn
Journal:  Mol Pharmacol       Date:  2015-03-25       Impact factor: 4.436

5.  The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors.

Authors:  Stephen P H Alexander; Helen E Benson; Elena Faccenda; Adam J Pawson; Joanna L Sharman; Michael Spedding; John A Peters; Anthony J Harmar
Journal:  Br J Pharmacol       Date:  2013-12       Impact factor: 8.739

6.  Recent advances in the design and development of novel negative allosteric modulators of mGlu(5).

Authors:  Kyle A Emmitte
Journal:  ACS Chem Neurosci       Date:  2011-08-17       Impact factor: 4.418

7.  Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain.

Authors:  Andrew S Doré; Krzysztof Okrasa; Jayesh C Patel; Maria Serrano-Vega; Kirstie Bennett; Robert M Cooke; James C Errey; Ali Jazayeri; Samir Khan; Ben Tehan; Malcolm Weir; Giselle R Wiggin; Fiona H Marshall
Journal:  Nature       Date:  2014-07-06       Impact factor: 49.962

8.  Ligands that interact with putative MOR-mGluR5 heteromer in mice with inflammatory pain produce potent antinociception.

Authors:  Eyup Akgün; Muhammad I Javed; Mary M Lunzer; Branden A Smeester; Al J Beitz; Philip S Portoghese
Journal:  Proc Natl Acad Sci U S A       Date:  2013-06-24       Impact factor: 11.205

Review 9.  Arylethynyl receptors for neutral molecules and anions: emerging applications in cellular imaging.

Authors:  Calden N Carroll; John J Naleway; Michael M Haley; Darren W Johnson
Journal:  Chem Soc Rev       Date:  2010-08-31       Impact factor: 54.564

Review 10.  Allosteric modulation of metabotropic glutamate receptors: structural insights and therapeutic potential.

Authors:  Karen J Gregory; Elizabeth N Dong; Jens Meiler; P Jeffrey Conn
Journal:  Neuropharmacology       Date:  2010-07-14       Impact factor: 5.250
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