| Literature DB >> 11814804 |
Adam McCluskey1, Mirella A Keane, Cecilia C Walkom, Michael C Bowyer, Alistair T R Sim, David J Young, Jennette A Sakoff.
Abstract
High pressure Diels-Alder reactions of furan and dimethylmaleate, and thiophene and maleimide resulted in two cantharidin analogues, 3 and 6 possessing PP1 selectivity (>40- and >30-fold selectivity) over PP2A. Both compounds exhibited moderate PP1 activity, 3 IC(50) 50 microM and 6 IC(50) 12.5 microM. Interestingly, the corresponding mono-ester derivatives of 3 showed no such selectivity.Entities:
Mesh：
Substances：
Year: 2002 PMID： 11814804 DOI： 10.1016/s0960-894x(01)00777-6
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823