| Literature DB >> 11814793 |
Ken-ichiro Hayashi1, Yuka Nakanishi, Kenneth F Bastow, Gordon Cragg, Hiroshi Nozaki, Kuo-Hsiung Lee.
Abstract
As part of a study on antitumor agents from rainforest plants, four new clerodane diterpenes, bucidarasins A--D (1-4), were isolated from Bucida buceras. Their structures were elucidated from detailed 2D NMR analyses. Compounds 1-3 showed potent cytotoxicity against human tumor cell lines with IC(50) values of 0.5-1.9 microM. The potency was retained in drug resistant lines.Entities:
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Year: 2002 PMID： 11814793 DOI： 10.1016/s0960-894x(01)00742-9
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823