Literature DB >> 11814789

Tyrosylprotein sulfotransferase inhibitors generated by combinatorial target-guided ligand assembly.

John W Kehoe1, Dustin J Maly, Dawn E Verdugo, Joshua I Armstrong, Brian N Cook, Ying-Bin Ouyang, Kevin L Moore, Jonathan A Ellman, Carolyn R Bertozzi.   

Abstract

Tyrosylprotein sulfotransferases (TPSTs) catalyze the sulfation of tyrosine residues within secreted and membrane-bound proteins. The modification modulates protein-protein interactions in the extracellular environment. Here we use combinatorial target-guided ligand assembly to discover the first known inhibitors of human TPST-2.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 11814789     DOI： 10.1016/s0960-894x(01)00744-2

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

Review 1.  Combinatorial chemistry as a new approach in antiparasitic drug discovery.

Authors:  Andreas Link
Journal:  Parasitol Res       Date:  2003-05-07       Impact factor: 2.289

2.  Mechanistic studies of beta-arylsulfotransferase IV.

Authors:  Eli Chapman; Marian C Bryan; Chi-Huey Wong
Journal:  Proc Natl Acad Sci U S A       Date:  2003-01-23       Impact factor: 11.205

Review 3.  New targets and inhibitors of mycobacterial sulfur metabolism.

Authors:  Hanumantharao Paritala; Kate S Carroll
Journal:  Infect Disord Drug Targets       Date:  2013-04

4.  Structure-based design of nucleoside-derived analogues as sulfotransferase inhibitors.

Authors:  Neil M Kershaw; Dominic P Byrne; Hollie Parsons; Neil G Berry; David G Fernig; Patrick A Eyers; Richard Cosstick
Journal:  RSC Adv       Date:  2019-10-09       Impact factor: 4.036

Review 5.  Drug targets in mycobacterial sulfur metabolism.

Authors:  Devayani P Bhave; Wilson B Muse; Kate S Carroll
Journal:  Infect Disord Drug Targets       Date:  2007-06

Review 6.  Recent development of two chitinase inhibitors, Argifin and Argadin, produced by soil microorganisms.

Authors:  Tomoyasu Hirose; Toshiaki Sunazuka; Satoshi Omura
Journal:  Proc Jpn Acad Ser B Phys Biol Sci       Date:  2010       Impact factor: 3.493

7.  New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors.

Authors:  Dominic P Byrne; Yong Li; Pawin Ngamlert; Krithika Ramakrishnan; Claire E Eyers; Carrow Wells; David H Drewry; William J Zuercher; Neil G Berry; David G Fernig; Patrick A Eyers
Journal:  Biochem J       Date:  2018-08-14       Impact factor: 3.857
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.