Literature DB >> 11814781

A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain.

Chester A Mathis1, Brian J Bacskai, Stephen T Kajdasz, Megan E McLellan, Matthew P Frosch, Bradley T Hyman, Daniel P Holt, Yanming Wang, Guo-Feng Huang, Manik L Debnath, William E Klunk.   

Abstract

The synthesis of a new lipophilic thioflavin-T analogue (2-[4' -(methylamino)phenyl]benzothiazole, 6) with high affinity for amyloid is reported. Intravenous injection of [(11)C]-labeled 6 in control mice resulted in high brain uptake. Amyloid deposits were imaged with multiphoton microscopy in the brains of living transgenic mice following the systemic injection of unlabeled 6. [(11)C]6 is a promising amyloid imaging agent for Alzheimer's disease.

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Year:  2002        PMID： 11814781     DOI： 10.1016/s0960-894x(01)00734-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  91 in total

1.  Drug discovery for Alzheimer's disease: the end of the beginning.

Authors:  Lorenzo M Refolo; Howard M Fillit
Journal:  J Mol Neurosci       Date:  2004       Impact factor: 3.444

2.  Early AD pathology in a [C-11]PiB-negative case: a PiB-amyloid imaging, biochemical, and immunohistochemical study.

Authors:  Milos D Ikonomovic; Eric E Abrahamson; Julie C Price; Ronald L Hamilton; Chester A Mathis; William R Paljug; Manik L Debnath; Anne D Cohen; Katsuyoshi Mizukami; Steven T DeKosky; Oscar L Lopez; William E Klunk
Journal:  Acta Neuropathol       Date:  2012-01-24       Impact factor: 17.088

Review 3.  Techniques for brain imaging in vivo.

Authors:  Monica Garcia-Alloza; Brian J Bacskai
Journal:  Neuromolecular Med       Date:  2004       Impact factor: 3.843

4.  Generation of Clickable Pittsburgh Compound B for the Detection and Capture of β-Amyloid in Alzheimer's Disease Brain.

Authors:  Ian Diner; Jeromy Dooyema; Marla Gearing; Lary C Walker; Nicholas T Seyfried
Journal:  Bioconjug Chem       Date:  2017-09-22       Impact factor: 4.774

5.  Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia.

Authors:  Eric M Reiman; Kewei Chen; Gene E Alexander; Richard J Caselli; Daniel Bandy; David Osborne; Ann M Saunders; John Hardy
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-19       Impact factor: 11.205

6.  Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-beta ligand in transgenic mice.

Authors:  Brian J Bacskai; Gregory A Hickey; Jesse Skoch; Stephen T Kajdasz; Yanming Wang; Guo-Feng Huang; Chester A Mathis; William E Klunk; Bradley T Hyman
Journal:  Proc Natl Acad Sci U S A       Date:  2003-09-29       Impact factor: 11.205

Review 7.  Amyloid imaging of Alzheimer's disease using Pittsburgh Compound B.

Authors:  Keith A Johnson
Journal:  Curr Neurol Neurosci Rep       Date:  2006-11       Impact factor: 5.081

8.  Tau Accumulation in Clinically Normal Older Adults Is Associated with Hippocampal Hyperactivity.

Authors:  Willem Huijbers; Aaron P Schultz; Kathryn V Papp; Molly R LaPoint; Bernard Hanseeuw; Jasmeer P Chhatwal; Trey Hedden; Keith A Johnson; Reisa A Sperling
Journal:  J Neurosci       Date:  2018-11-27       Impact factor: 6.167

9.  Visualization of beta-amyloid plaques in a transgenic mouse model of Alzheimer's disease using MR microscopy without contrast reagents.

Authors:  Sang-Pil Lee; Maria F Falangola; Ralph A Nixon; Karen Duff; Joseph A Helpern
Journal:  Magn Reson Med       Date:  2004-09       Impact factor: 4.668

10.  The binding of thioflavin T and its neutral analog BTA-1 to protofibrils of the Alzheimer's disease Abeta(16-22) peptide probed by molecular dynamics simulations.

Authors:  Chun Wu; Zhixiang Wang; Hongxing Lei; Yong Duan; Michael T Bowers; Joan-Emma Shea
Journal:  J Mol Biol       Date:  2008-10-07       Impact factor: 5.469
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