Literature DB >> 11814775

New generation dopaminergic agents. Part 8: heterocyclic bioisosteres that exploit the 7-OH-2-(aminomethyl)chroman D(2) template.

Richard E Mewshaw1, Rulin Zhao, Xiaojie Shi, Karen Marquis, Julie A Brennan, Hossein Mazandarani, Joseph Coupet, Terrance H Andree.   

Abstract

Based on the 7-OH-2-(aminomethyl)chroman dopamine D(2) template (2) is described the preparation and resolution of two bioisosteric analogues. The benzimidazol-2-one derivative (6) had similar affinity to the known indolone derivative (4).

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Year:  2002        PMID: 11814775     DOI: 10.1016/s0960-894x(01)00778-8

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

1.  Palladium-catalyzed coupling reactions on functionalized 2-trifluoromethyl-4-chromenone scaffolds. Synthesis of highly functionalized trifluoromethyl-heterocycles.

Authors:  Javier Izquierdo; Atul D Jain; Sarki A Abdulkadir; Gary E Schiltz
Journal:  Synthesis (Stuttg)       Date:  2019-03       Impact factor: 3.157

2.  Design, Synthesis, and Biological Evaluation of Phenol Bioisosteric Analogues of 3-Hydroxymorphinan.

Authors:  Ziqiang Li; Xiuqi Bao; Xiaoguang Bai; Guoning Zhang; Juxian Wang; Mei Zhu; Yue Wang; Junmei Shang; Chanjuan Sheng; Dan Zhang; Yucheng Wang
Journal:  Sci Rep       Date:  2019-02-19       Impact factor: 4.379

  2 in total

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