Literature DB >> 11814631

Investigation of substance P transport across the blood-brain barrier.

Anita L Freed1, Kenneth L Audus, Susan M Lunte.   

Abstract

The transport of substance P (SP) was investigated using the bovine brain microvessel endothelial cell culture model of the blood-brain barrier (BBB). The samples were derivatized precolumn with naphthalene dialdehyde, then analyzed by cyclodextrin-modified micellar electrokinetic chromatography with laser-induced fluorescence detection. SP crossed the BBB in both the apical-to-basolateral and basolateral-to-apical directions through an active transport mechanism. The transport of SP from the apical side was demonstrated to be via transcytosis. The N-terminal (SP(1-4)) and C-terminal (SP(3-11)) fragments were also found to permeate the BBB from the apical side.

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Year:  2002        PMID： 11814631     DOI： 10.1016/s0196-9781(01)00592-7

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  9 in total

1.  Characteristics of substance P transport across the blood-brain barrier.

Authors:  Arvind K Chappa; Kenneth L Audus; Susan M Lunte
Journal:  Pharm Res       Date:  2006-06-01       Impact factor: 4.200

Review 2.  Substance P receptor antagonists in psychiatry: rationale for development and therapeutic potential.

Authors:  Inga Herpfer; Klaus Lieb
Journal:  CNS Drugs       Date:  2005       Impact factor: 5.749

Review 3.  Drug delivery to the brain in Alzheimer's disease: consideration of the blood-brain barrier.

Authors:  William A Banks
Journal:  Adv Drug Deliv Rev       Date:  2011-12-17       Impact factor: 15.470

Review 4.  Analytical and biological methods for probing the blood-brain barrier.

Authors:  Courtney D Kuhnline Sloan; Pradyot Nandi; Thomas H Linz; Jane V Aldrich; Kenneth L Audus; Susan M Lunte
Journal:  Annu Rev Anal Chem (Palo Alto Calif)       Date:  2012       Impact factor: 10.745

5.  Utilization of the least shrew as a rapid and selective screening model for the antiemetic potential and brain penetration of substance P and NK1 receptor antagonists.

Authors:  Nissar A Darmani; Yaozhi Wang; Joseph Abad; Andrew P Ray; Gerald R Thrush; Juan Ramirez
Journal:  Brain Res       Date:  2008-04-09       Impact factor: 3.252

6.  Ablation of least shrew central neurokinin NK1 receptors reduces GR73632-induced vomiting.

Authors:  Andrew P Ray; Seetha Chebolu; Juan Ramirez; Nissar A Darmani
Journal:  Behav Neurosci       Date:  2009-06       Impact factor: 1.912

7.  Neurokinin-1 receptor activation is sufficient to restore the hypercapnic ventilatory response in the Substance P-deficient naked mole-rat.

Authors:  Maxwell S Clayson; Maiah E M Devereaux; Matthew E Pamenter
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2020-01-22       Impact factor: 3.619

8.  Pharmacokinetics of aprepitant and dexamethasone after administration of chemotherapeutic agents and effects of plasma substance P concentration on chemotherapy-induced nausea and vomiting in Japanese cancer patients.

Authors:  Toshiaki Takahashi; Yukiko Nakamura; Asuka Tsuya; Haruyasu Murakami; Masahiro Endo; Nobuyuki Yamamoto
Journal:  Cancer Chemother Pharmacol       Date:  2010-12-02       Impact factor: 3.333

Review 9.  Mechanisms of Nausea and Vomiting: Current Knowledge and Recent Advances in Intracellular Emetic Signaling Systems.

Authors:  Weixia Zhong; Omar Shahbaz; Garrett Teskey; Abrianna Beever; Nala Kachour; Vishwanath Venketaraman; Nissar A Darmani
Journal:  Int J Mol Sci       Date:  2021-05-28       Impact factor: 5.923
  9 in total

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