| Literature DB >> 11814312 |
E Jablonska1, L Piotrowski, M Kiluk, J Jablonski, Z Grabowska, W Markiewicz.
Abstract
In the present study, we demonstrate an effect of rhIL-15 on the simultaneous secretion of IL-1beta and its natural inhibitors IL-1Ra and sIL-1RII by human neutrophils isolated from normal and tumour-bearing hosts (oral cavity cancer and melanoma patients) compared with serum IL-15 levels. We found an rhIL-15 influence on IL-beta and IL-1Ra secreted by PMN from healthy controls. In contrast, the PMNs from cancer patients were not sensitive to rhIL-15 stimulation. However, we found a priming effect of rhIL-15 on IL-1beta production by LPS-stimulated cells in oral cavity cancer. We also found no effect on sIL-1RII release by PMN from cancer patients. Copyright 2001 Academic Press.Entities:
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Year: 2001 PMID： 11814312 DOI： 10.1006/cyto.2001.0931
Source DB: PubMed Journal: Cytokine ISSN： 1043-4666 Impact factor: 3.861