J Bu1, J Pang, R Bu. 1. Department of Stomatology, General Hospital of PLA, Beijing 100853, China.
Abstract
OBJECTIVE: To explore the role of human papillomavirus (HPV) infection on carcinogenesis of oral squamous cell papillomas (SCP). METHODS: By using digoxin labelled HPV 6/11 and HPV 16/18 probes, through hybridization in situ technique, the HPV DNA sequence in 30 cases of oral SCP were detected. RESULTS: Among them, 16 cases (53.3%) were positive for HPV 6/11 DNA. None of cases of SCP were positive for HPV 16/18 DNA. CONCLUSION: Our results show that the frequent finding of HPV 6/11 DNA in oral SCP had close association between oral papillomas and HPV 6/11 infection.
OBJECTIVE: To explore the role of human papillomavirus (HPV) infection on carcinogenesis of oral squamous cell papillomas (SCP). METHODS: By using digoxin labelled HPV 6/11 and HPV 16/18 probes, through hybridization in situ technique, the HPV DNA sequence in 30 cases of oral SCP were detected. RESULTS: Among them, 16 cases (53.3%) were positive for HPV 6/11 DNA. None of cases of SCP were positive for HPV 16/18 DNA. CONCLUSION: Our results show that the frequent finding of HPV 6/11 DNA in oral SCP had close association between oral papillomas and HPV 6/11 infection.