Literature DB >> 11810510

Estimation of outer membrane permeability of carbapenem antibiotics to Pseudomonas aeruginosa.

S. Iyobe1, Masato Watanabe, Susumu Mitsuhashi, M. Inoue.   

Abstract

The outer membrane permeability of carbapenems (imipenem [IPM], panipenem [PAPM], meropenem [MEPM], and biapenem [BIPM]) and ceftazidime (CAZ) to Pseudomonas aeruginosa was determined by the Zimmermann and Rosselet method. The permeability coefficients of beta-lactams tested at 50 &mgr;M concentration of substrates ranged from (0.40 +/- 0.10) x 10-6 cm/s for CAZ to (2.33 +/- 0.33) x 10-6 cm/s for IPM, indicating that the outer membrane permeability of carbapenems to P. aeruginosa was high in comparison with that of CAZ. In particular, IPM and BIPM showed a higher rate of penetration than MEPM and PAPM.

Entities:  

Year:  1999        PMID： 11810510     DOI： 10.1007/s101560050028

Source DB:  PubMed          Journal:  J Infect Chemother        ISSN： 1341-321X            Impact factor:   2.211


  5 in total

1.  Comparable Efficacy and Better Safety of Double β-Lactam Combination Therapy versus β‑Lactam plus Aminoglycoside in Gram-Negative Bacteria in Randomized, Controlled Trials.

Authors:  Yuanyuan Jiao; Bartolome Moya; Mong-Jen Chen; Alexandre P Zavascki; Hsinyin Tsai; Xun Tao; Dhruvitkumar S Sutaria; Arnold Louie; John D Boyce; Deanna Deveson Lucas; Tae Hwan Kim; Brian T Tsuji; Robert A Bonomo; George L Drusano; Jürgen B Bulitta
Journal:  Antimicrob Agents Chemother       Date:  2019-06-24       Impact factor: 5.191

Review 2.  Four Decades of β-Lactam Antibiotic Pharmacokinetics in Cystic Fibrosis.

Authors:  Jürgen B Bulitta; Yuanyuan Jiao; Stefanie K Drescher; Antonio Oliver; Arnold Louie; Bartolome Moya; Xun Tao; Mathias Wittau; Brian T Tsuji; Alexandre P Zavascki; Beom Soo Shin; George L Drusano; Fritz Sörgel; Cornelia B Landersdorfer
Journal:  Clin Pharmacokinet       Date:  2019-02       Impact factor: 6.447

3.  The Whole Is Bigger than the Sum of Its Parts: Drug Transport in the Context of Two Membranes with Active Efflux.

Authors:  Valentin V Rybenkov; Helen I Zgurskaya; Chhandosee Ganguly; Inga V Leus; Zhen Zhang; Mohammad Moniruzzaman
Journal:  Chem Rev       Date:  2021-02-17       Impact factor: 60.622

4.  First Penicillin-Binding Protein Occupancy Patterns for 15 β-Lactams and β-Lactamase Inhibitors in Mycobacterium abscessus.

Authors:  Alaa R M Sayed; Nirav R Shah; Kari B Basso; Manasi Kamat; Yuanyuan Jiao; Bartolome Moya; Dhruvitkumar S Sutaria; Yinzhi Lang; Xun Tao; Weiguo Liu; Eunjeong Shin; Jieqiang Zhou; Carolin Werkman; Arnold Louie; George L Drusano; Jürgen B Bulitta
Journal:  Antimicrob Agents Chemother       Date:  2020-12-16       Impact factor: 5.938

5.  Novel Cassette Assay To Quantify the Outer Membrane Permeability of Five β-Lactams Simultaneously in Carbapenem-Resistant Klebsiella pneumoniae and Enterobacter cloacae.

Authors:  Tae Hwan Kim; Xun Tao; Bartolome Moya; Yuanyuan Jiao; Kari B Basso; Jieqiang Zhou; Yinzhi Lang; Dhruvitkumar S Sutaria; Alexandre P Zavascki; Afonso L Barth; Stephanie M Reeve; Herbert P Schweizer; Deanna Deveson Lucas; John D Boyce; Robert A Bonomo; Richard E Lee; Beom Soo Shin; Arnold Louie; George L Drusano; Jürgen B Bulitta
Journal:  mBio       Date:  2020-02-11       Impact factor: 7.867
  5 in total

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