| Literature DB >> 11809259 |
Nobukazu Ishizaka, Yuko Ishizaka, Eiko Takahashi, Ei ichi Tooda, Hideki Hashimoto, Ryozo Nagai, Minoru Yamakado.
Abstract
We investigated the relation between positivity for hepatitis C virus (HCV) and carotid-artery plaque and carotid intima-media thickening by analysing cross-sectional data of individuals undergoing a general health screening test. Of 4784 individuals enrolled, 104 (2.2%) were seropositive for HCV. After adjustment for confounding risk factors, HCV seropositivity was found to be associated with an increased risk of carotid-artery plaque (odds ratio 1.92 [95% CI 1.56-2.38], p=0.002) and carotid intima-media thickening (2.85 [2.28-3.57], p<0.0001). These findings suggest a possible role for chronic hepatitis C in the pathogenesis of carotid arterial remodelling.Entities:
Mesh:
Year: 2002 PMID: 11809259 DOI: 10.1016/s0140-6736(02)07339-7
Source DB: PubMed Journal: Lancet ISSN: 0140-6736 Impact factor: 79.321