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Literature DB >> 11809075

Indole and beta-carboline alkaloids from Geissospermum sericeum.

Jonathan C P Steele¹, Nigel C Veitch, Geoffrey C Kite, Monique S J Simmonds, David C Warhurst.

Abstract

The indole alkaloid geissoschizoline (1) and two new derivatives, geissoschizoline N(4)-oxide (2) and 1,2-dehydrogeissoschizoline (3), were obtained from the bark of Geissospermum sericeum together with the beta-carboline alkaloid flavopereirine (4). The in vitro antiplasmodial activity of these compounds was evaluated in chloroquine-resistant (K1) and chloroquine-sensitive (T9-96) Plasmodium falciparum. Their cytotoxicity was determined in a human (KB) cell line.

Entities: Chemical Disease Species

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Year: 2002 PMID： 11809075 DOI： 10.1021/np0101705

Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050

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Cited

10 in total

1. Biomimetic Total Syntheses of (-)-Leucoridines A and C through the Dimerization of (-)-Dihydrovalparicine.

Authors: Praveen Kokkonda; Keaon R Brown; Trevor J Seguin; Steven E Wheeler; Shivaiah Vaddypally; Michael J Zdilla; Rodrigo B Andrade
Journal: Angew Chem Int Ed Engl Date: 2015-08-28 Impact factor: 15.336

2. Brønsted acid mediated cyclization of enaminones. Rapid and efficient access to the tetracyclic framework of the Strychnos alkaloids.

Authors: Rahul V Edwankar; Chitra R Edwankar; Ojas A Namjoshi; Jeffrey R Deschamps; James M Cook
Journal: J Nat Prod Date: 2012-01-18 Impact factor: 4.050

Indole and beta-carboline alkaloids from Geissospermum sericeum.

1. Biomimetic Total Syntheses of (-)-Leucoridines A and C through the Dimerization of (-)-Dihydrovalparicine.

2. Brønsted acid mediated cyclization of enaminones. Rapid and efficient access to the tetracyclic framework of the Strychnos alkaloids.

3. Theoretical study of the regioselective cyclization of enaminones in the construction of benzofurans and indoles.

Review 4. Analysis of additivity and synergism in the anti-plasmodial effect of purified compounds from plant extracts.

5. Extract of the Medicinal Plant Pao Pereira Inhibits Pancreatic Cancer Stem-Like Cell In Vitro and In Vivo.

6. Pao Pereira Extract Attenuates Testosterone-Induced Benign Prostatic Hyperplasia in Rats by inhibiting 5α-Reductase.

7. Geissospermiculatine, a New Alkaloid from Geissospermum reticulatum Bark.

8. Plants used traditionally to treat malaria in Brazil: the archives of Flora Medicinal.

9. Nukuhivensiums, indolo[2,3-a]quinoliziniums from the Marquesan plant Rauvolfia nukuhivensis.

10. Flavopereirine Inhibits Autophagy via the AKT/p38 MAPK Signaling Pathway in MDA-MB-231 Cells.