| Literature DB >> 11809069 |
Youngwan Seo1, John M Berger, Jeannine Hoch, Kim M Neddermann, Isia Bursuker, Steven W Mamber, David G I Kingston.
Abstract
A novel triterpenoid saponin, pittoviridoside (1), which possesses an unusual 2,3,4-trisubstituted glycosidic linkage, has been isolated from Pittosporum viridiflorum using the engineered yeast strains 1138, 1140, 1353, and Sc-7 for bioactivity-guided fractionation. The structure of this compound was determined to be 3-O-[beta-D-glucopyranosyl(1-->2)]-[alpha-D-arabinopyranosyl(1-->3)],[alpha-l-arabinofuranosyl(1-->4)-beta-D-glucuronopyranosyl-21-angeloyl-22-senecioylolean-12-en-3beta,15alpha,16alpha,21beta,22alpha,28-hexol by spectral, chemical, and GC analyses. This compound showed weak cytotoxicity against the A2780 human ovarian cancer cell line.Entities:
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Year: 2002 PMID： 11809069 DOI： 10.1021/np010327t
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050