Literature DB >> 1180885

Induction of 16alpha-hydroxylase in cultured human lymphocytes.

I E Muijsson, M L Coomes, E T Cantrell, D E Anderson, D L Busbee.   

Abstract

Lymphocytes grown for 72 hr in the presence of mitogenic agents exhibited a nine-fold increase in 16alpha-hydroxylase activity over a 24-hr period following the addition of 17beta-estradiol as an inducing agent. The major metabolite of 17beta-estradiol produced by induced lymphocytes showed a chromatographic mobility indistinguishable from that of estriol. Enzymatic activity increased linearly with cell numbers, was inhibited by CO, and exhibited no induced increase in the presence of cycloheximide. A population survey indicated about 68% of a randomly selected Caucasian group to be essentially uninducible for 16alpha-hydroxylase.

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Year:  1975        PMID： 1180885     DOI： 10.1007/bf00485791

Source DB:  PubMed          Journal:  Biochem Genet        ISSN： 0006-2928            Impact factor:   1.890


  19 in total

1.  Estrophile to nucleophile in two easy steps.

Authors:  E V Jensen; S Mohla; T Gorell; S Tanaka; E R DeSombre
Journal:  J Steroid Biochem       Date:  1972-04       Impact factor: 4.292

2.  Conjugation of steroid hormones by breast cancer tissue and selection of patients for adrenalectomy.

Authors:  T L Dao; P R Libby
Journal:  Surgery       Date:  1969-07       Impact factor: 3.982

3.  The enzymatic catabolism of hemoglobin: stimulation of microsomal heme oxygenase by hemin.

Authors:  R Tenhunen; H S Marver; R Schmid
Journal:  J Lab Clin Med       Date:  1970-03

4.  The effect of phenobarbital, 3-methylcholanthrene, 3,4-benzpyrene, and pregnenolone-16 alpha-carbonitrile on microsomal heme oxygenase and splenic cytochrome P-450.

Authors:  B A Schacter; J I Mason
Journal:  Arch Biochem Biophys       Date:  1974-01       Impact factor: 4.013

Review 5.  Control by estrogen of genetic transcription and translation. Binding to chromatin and stimulation of nucleolar RNA synthesis are primary events in the early estrogen action.

Authors:  T H Hamilton
Journal:  Science       Date:  1968-08-16       Impact factor: 47.728

6.  Relation of prolactin and estrogen to mammary tumorigenesis in the rat.

Authors:  J Meites
Journal:  J Natl Cancer Inst       Date:  1972-04       Impact factor: 13.506

7.  The induction of aryl hydrocarbon and estrogen hydroxylases in the rough and smooth endoplasmic reticulum in regenerating rat liver.

Authors:  P W Fischer; T Spencer
Journal:  Chem Biol Interact       Date:  1972-06       Impact factor: 5.192

8.  Family history of breast carcinoma in women predisposed to develop breast carcinoma.

Authors:  C D Haagensen
Journal:  J Natl Cancer Inst       Date:  1972-04       Impact factor: 13.506

9.  Genetic predisposition to carcinoma of the breast: multiple human genotypes for estrogen 16 alpha hydroxylase activity in Caucasians.

Authors:  H M Lemon
Journal:  J Surg Oncol       Date:  1972       Impact factor: 3.454

10.  The role of genetics in human cancer.

Authors:  D E Anderson
Journal:  CA Cancer J Clin       Date:  1974 May-Jun       Impact factor: 508.702
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  2 in total

1.  Aryl hydrocarbon hydroxylase and 16alpha-hydroxylase in cultured human lymphocytes.

Authors:  M L Coomes; W A Mason; I E Muijsson; E T Cantrell; D E Anderson; D L Busbee
Journal:  Biochem Genet       Date:  1976-08       Impact factor: 1.890

2.  Short-term and long-term effects of estrogen on lymphoid tissues and lymphoid cells with some remarks on the significance for carcinogenesis.

Authors:  J G Forsberg
Journal:  Arch Toxicol       Date:  1984-07       Impact factor: 5.153
  2 in total

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