| Literature DB >> 11807785 |
Fulvio Basolo1, Riccardo Giannini, Antonio Toniolo, Rosario Casalone, Marina Nikiforova, Furio Pacini, Rossella Elisei, Paolo Miccoli, Piero Berti, Pinuccia Faviana, Lisa Fiore, Carmen Monaco, Giovanna Maria Pierantoni, Monica Fedele, Yuri E Nikiforov, Massimo Santoro, Alfredo Fusco.
Abstract
A novel human thyroid papillary carcinoma cell line (FB-2) has been established and characterized. FB-2 cells harbor the RET/PTC1 chimeric oncogene in which the RET kinase domain is fused to the H4 gene. FB-2 cells neither formed colonies in semisolid media nor induced tumors after heterotransplant into severe combined immunodeficient mice. However, HMGI(Y), HMGI-C and c-myc genes, which are associated to thyroid cell transformation, were abundantly expressed in FB-2 cells but not in normal thyroid cells. FB-2 cells only partially retained the differentiated thyroid phenotype. In fact, the PAX-8 gene, which codes for a transcriptional factor required for thyroid cell differentiation, was expressed, while thyroglobulin, TSH-receptor and thyroperoxidase genes were not. Moreover, FB-2 cells produced high levels of interleukin (IL)-6 and IL-8. Copyright 2001 Wiley-Liss, Inc.Entities:
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Year: 2002 PMID： 11807785 DOI： 10.1002/ijc.10116
Source DB: PubMed Journal: Int J Cancer ISSN： 0020-7136 Impact factor: 7.396