| Literature DB >> 11805265 |
A Hartmann1, A Mouatt-Prigent, B A Faucheux, Y Agid, E C Hirsch.
Abstract
Fas-associating protein with a death domain (FADD) is a proximal adaptor protein of the tumor necrosis factor (TNF) receptor family death pathway. This human postmortem study showed a significant decrease in the percentage of FADD-immunoreactive dopaminergic (DA) neurons in the substantia nigra pars compacta of patients with PD compared with controls (-24.8%). This decrease correlated with the known selective vulnerability of nigral DA neurons in PD, suggesting that this pathway contributes to the susceptibility of DA neurons in PD to TNF-mediated apoptosis.Entities:
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Year: 2002 PMID： 11805265 DOI： 10.1212/wnl.58.2.308
Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910