Literature DB >> 11805070

A simple formula useful for positional cloning.

Richard T Durrett1, Kai-Yi Chen, Steven D Tanksley.   

Abstract

We derive a formula for the distribution of the length T of the recombination interval containing a target gene and using N gametes in a region where R kilobases correspond to 1 cM. The formula can be used to calculate the number of meiotic events required to narrow a target gene down to a specific interval size and hence should be useful for planning positional cloning experiments. The predictions of this formula agree well with the results from a number of published experiments in Arabidopsis.

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Year:  2002        PMID： 11805070      PMCID： PMC1461938     

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


  4 in total

Review 1.  Positional cloning in Arabidopsis. Why it feels good to have a genome initiative working for you.

Authors:  W Lukowitz; C S Gillmor; W R Scheible
Journal:  Plant Physiol       Date:  2000-07       Impact factor: 8.340

2.  Assaying genome-wide recombination and centromere functions with Arabidopsis tetrads.

Authors:  G P Copenhaver; W E Browne; D Preuss
Journal:  Proc Natl Acad Sci U S A       Date:  1998-01-06       Impact factor: 11.205

Review 3.  Chromosome landing: a paradigm for map-based gene cloning in plants with large genomes.

Authors:  S D Tanksley; M W Ganal; G B Martin
Journal:  Trends Genet       Date:  1995-02       Impact factor: 11.639

4.  The Arabidopsis HY2 gene encodes phytochromobilin synthase, a ferredoxin-dependent biliverdin reductase.

Authors:  T Kohchi; K Mukougawa; N Frankenberg; M Masuda; A Yokota; J C Lagarias
Journal:  Plant Cell       Date:  2001-02       Impact factor: 11.277
  4 in total
  6 in total

1.  A bacterial artificial chromosome (BAC) library of sugar beet and a physical map of the region encompassing the bolting gene B.

Authors:  U Hohmann; G Jacobs; A Telgmann; R M Gaafar; S Alam; C Jung
Journal:  Mol Genet Genomics       Date:  2003-03-01       Impact factor: 3.291

2.  Random mutagenesis of proximal mouse chromosome 5 uncovers predominantly embryonic lethal mutations.

Authors:  Lawriston Wilson; Yung-Hao Ching; Michael Farias; Suzanne A Hartford; Gareth Howell; Hongguang Shao; Maja Bucan; John C Schimenti
Journal:  Genome Res       Date:  2005-07-15       Impact factor: 9.043

3.  A bacterial artificial chromosome contig spanning the major domestication locus Q in wheat and identification of a candidate gene.

Authors:  Justin D Faris; John P Fellers; Steven A Brooks; Bikram S Gill
Journal:  Genetics       Date:  2003-05       Impact factor: 4.562

4.  Combining DNA pooling with selective recombinant genotyping for increased efficiency in fine mapping.

Authors:  Xiao-Fei Chi; Xiang-Yang Lou; Qing-Yao Shu
Journal:  Theor Appl Genet       Date:  2009-11-08       Impact factor: 5.699

5.  Predicting the size of the progeny mapping population required to positionally clone a gene.

Authors:  Stephen J Dinka; Matthew A Campbell; Tyler Demers; Manish N Raizada
Journal:  Genetics       Date:  2007-06-11       Impact factor: 4.562

Review 6.  ENU mutagenesis screen to establish motor phenotypes in wild-type mice and modifiers of a pre-existing motor phenotype in tau mutant mice.

Authors:  Xin Liu; Michael Dobbie; Rob Tunningley; Belinda Whittle; Yafei Zhang; Lars M Ittner; Jürgen Götz
Journal:  J Biomed Biotechnol       Date:  2011-12-15
  6 in total

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