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Literature DB >> 1180486

Centrometric linkage in autosomal trisomies.

Abstract

A detailed description of the cytological mechanisms leading to autosomal trisomy shows that the proportion of trisomics carrying three alleles from three of their grandparents is bound to be greater than zero for any locus anywhere on a trisomic chromosome. The likelihood method used to estimate this proportion in pedigree data can be applied to the detection of linkage, or to investigations on the origin of trisomy when linkage is known.

Mesh：

Year: 1975 PMID： 1180486 DOI： 10.1111/j.1469-1809.1975.tb00107.x

Source DB: PubMed Journal: Ann Hum Genet ISSN： 0003-4800 Impact factor: 1.670

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Cited

6 in total

1. On the origin of the supernumerary chromosome in autosomal trisomies--with special reference to Down's syndrome. A bias in tracing nondisjunction by chromosomal and biochemical polymorphisms.

Authors: U Langenbeck; I Hansmann; B Hinney; V Hönig
Journal: Hum Genet Date: 1976-07-27 Impact factor: 4.132

Centrometric linkage in autosomal trisomies.

1. On the origin of the supernumerary chromosome in autosomal trisomies--with special reference to Down's syndrome. A bias in tracing nondisjunction by chromosomal and biochemical polymorphisms.

2. Statistical analysis of half-tetrads.

3. Use of restriction fragment length polymorphic probes in the analysis of Down's syndrome trisomy.

4. Multilocus analysis for gene-centromere mapping using first polar bodies and secondary oocytes.

5. Multipoint estimation of genetic maps for human trisomies with one parent or other partial data.

6. Mapping centromeres of microchromosomes in the zebra finch (Taeniopygia guttata) using half-tetrad analysis.