Interplay of orbital symmetry and nonstatistical dynamics in the thermal rearrangements of bicyclo[n.1.0]polyenes.

CASSCF and CASPT2 calculations have been carried out on some of the thermal rearrangements of bicyclo[2.1.0]pentene (BCP), bicyclo[4.1.0]hepta-2,4-diene (BCH), bicyclo[6.1.0]nona-2,4,6-triene (BCN), and 9,9-dicyanobicyclo[6.1.0]nona-2,4,6-triene (DCBCN). In addition, experiments have been conducted to determine the stereoselectivity and temperature dependence of the nondegenerate rearrangement of 9,9-dicyanobicyclo[6.1.0]nona-2,4,6-triene-exo-15N. The calculations and experiments allow a consistent picture to be drawn for these reactions. The principal conclusions are as follows. (1) The ring-walk rearrangements of BCP, BCN, and DCBCN are pericyclic reactions occurring with a strong preference for inversion of configuration at the migrating carbon. However, the ring-walk rearrangement of BCH is a nonpericyclic reaction. (2) The rearrangement of DCBCN to 9,9-dicyanobicyclo[4.2.1]nona-2,4,7-triene occurs with a preferred stereochemistry corresponding to a 1,3 migration with retention. However, this reaction is not a pericyclic process; the stereoselectivity is probably of dynamic origin. (3) Cyano substituents can significantly reduce the activation energy for a reaction occurring via a singlet biradical, but they do not necessarily cause the intermediate to sit in a deeper local minimum on the potential energy surface.