| Literature DB >> 11804488 |
Taoues Temal-Laïb1, Jacqueline Chastanet, Jieping Zhu.
Abstract
A general strategy for the synthesis of cyclopeptide alkaloids containing an endocyclic aryl-alkyl ether bond has been developed featuring a key intramolecular S(N)Ar reaction. The importance of the N-terminal protective group in the realization of such a strategy is documented. From the appropriate amino acid constituents, the natural sanjoinine G1, a 14-membered para cyclophane, has been synthesized in seven steps with 21% overall yield.Entities:
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Year: 2002 PMID： 11804488 DOI： 10.1021/ja0170807
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419