| Literature DB >> 11804473 |
Bin Cao1, Haengsoon Park, Madeleine M Joullié.
Abstract
The total synthesis of ustiloxin D, a highly potent inhibitor of microtubule assembly, has been achieved. Notable features are the use of nucleophilic aromatic substitution (SNAr) for the construction of a chiral tertiary alkyl-aryl ether linkage, Sharpless asymmetric aminohydroxylation for the formation of the beta-hydroxytyrosine moiety, macrolactamization, and regioselective methylation.Entities:
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Year: 2002 PMID： 11804473 DOI： 10.1021/ja017277z
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419