| Literature DB >> 11803360 |
M Mohty1, C Faucher, B Gaugler, N Vey, D Sainty, C Arnoulet, M J Mozziconacci, D Isnardon, J A Gastaut, D Maraninchi, D Olive, D Blaise.
Abstract
We report here the first case of large granular lymphocytes (LGL) expansion following non-myeloablative allo-BMT for chronic myeloid leukemia. We characterized the morphologic, phenotypic and functional features of the LGL subset amplified in vivo 14 months after allo-BMT. Our results indicate that LGL can mediate in vitro a cytolytic activity on tumor cells. In vivo, the timing of the LGL expansion was associated with a sustained complete molecular remission. These observations suggest that LGL are a subset with the properties of effector lymphocytes which may contribute to the graft-versus-tumor effect.Entities:
Mesh：
Year: 2001 PMID： 11803360 DOI： 10.1038/sj.bmt.1703308
Source DB: PubMed Journal: Bone Marrow Transplant ISSN： 0268-3369 Impact factor: 5.483