D Ding1, Q Deng, H Zhang. 1. Department of Respiratory Medicine, Shanxian Central Hospital, Shanxian 274300, China.
Abstract
OBJECTIVE: To investigate the effects of intrapleural urokinase in the prevention of pleural thickening and loculated pleural effusions by tuberculous pleural effusion. METHOD:Eighty-one patients with tuberculous pleural effusion were randomized into 2 groups, intrapleural urokinase group (group I) and conventional group (group C). The patients in group I were injected with urokinase 100 000 IU intrapleurally after each thoracocentesis on twice a week basis, other therapies were similar to group C. RESULTS: The mean volume of fluid drained in group I was (3 981 +/- 573) ml, while it was (3 045 +/- 498) ml in group C (P < 0.01). The mean thickness of pleura in group I was (1.10 +/- 0.20) mm, but it was (1.40 +/- 0.30) mm in group C (P < 0.01), the incidence of pleural adhesion and location in group I was 10%, while it was 36% in group C (P < 0.01). The mean number of injection was (4.6 +/- 1.4) (ranged 3 approximately 8). The resolution time of pleural effusion was prolonged slightly, but there was no significant difference between two groups. CONCLUSION:Intrapleural urokinase can evidently increase the volume of pleural effusion drained and prevent pleural thickening and adhesion.
RCT Entities:
OBJECTIVE: To investigate the effects of intrapleural urokinase in the prevention of pleural thickening and loculated pleural effusions by tuberculous pleural effusion. METHOD: Eighty-one patients with tuberculous pleural effusion were randomized into 2 groups, intrapleural urokinase group (group I) and conventional group (group C). The patients in group I were injected with urokinase 100 000 IU intrapleurally after each thoracocentesis on twice a week basis, other therapies were similar to group C. RESULTS: The mean volume of fluid drained in group I was (3 981 +/- 573) ml, while it was (3 045 +/- 498) ml in group C (P < 0.01). The mean thickness of pleura in group I was (1.10 +/- 0.20) mm, but it was (1.40 +/- 0.30) mm in group C (P < 0.01), the incidence of pleural adhesion and location in group I was 10%, while it was 36% in group C (P < 0.01). The mean number of injection was (4.6 +/- 1.4) (ranged 3 approximately 8). The resolution time of pleural effusion was prolonged slightly, but there was no significant difference between two groups. CONCLUSION: Intrapleural urokinase can evidently increase the volume of pleural effusion drained and prevent pleural thickening and adhesion.