| Literature DB >> 11802771 |
John J Murphy1, Paul Hobby, Juan Vilarino-Varela, Benjamin Bishop, Panagiota Iordanidou, Brian J Sutton, John D Norton.
Abstract
A novel lymphocyte-specific immunoglobulin superfamily protein (19A) has been cloned. The predicted 335-amino-acid sequence of 19A represents a Type 1 membrane protein with homology with the CD2 family of receptors. A molecular model of the two predicted extracellular immunoglobulin-like domains of 19A has been generated using the crystal structure of CD2 as a template. In isolated lymphocytes, expression of 19A is induced by various activation stimuli, and enforced expression of the 19A gene promotes homotypic cell adhesion in a B-cell-line model. Collectively these data imply that the 19A protein plays a role in regulation of lymphocyte adhesion.Entities:
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Year: 2002 PMID： 11802771 PMCID： PMC1222324 DOI： 10.1042/0264-6021:3610431
Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857