Literature DB >> 11802662

Inhibition of neutrophil elastase activity by phenolic compounds from plants.

M F Melzig1, B Löser, S Ciesielski.   

Abstract

The influence of 40 phenolic compounds from plants were tested on the enzymatic activity of neutrophil elastase (EC 3.4.21.37). Among the flavonoids especially the compounds with a catecholic structure showed a strong inhibitory activity in the range of mumol/l, hyperosid was the strongest inhibitor with an IC50 of about 0.3 mumol/l. Lipophilic caffeic acid esters and phenolic compounds with catecholic structure elements in general inhibited the enzyme. Because of the specific role of neutrophil elastase in the inflammatory process its inhibition by phenolic natural compounds might be one explanation for the use of medicinal plants containing phenolic compounds in the treatment of inflammation.

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Year:  2001        PMID： 11802662

Source DB:  PubMed          Journal:  Pharmazie        ISSN： 0031-7144            Impact factor:   1.267


  9 in total

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7.  Anti-collagenase, anti-elastase and anti-oxidant activities of extracts from 21 plants.

Authors:  Tamsyn S A Thring; Pauline Hili; Declan P Naughton
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8.  Inhibition of human neutrophil elastase by pentacyclic triterpenes.

Authors:  Li Feng; Xiaoyu Liu; Weiliang Zhu; Fujiang Guo; Yingchun Wu; Rui Wang; Kaixian Chen; Cheng Huang; Yiming Li
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9.  Anti-aging potential of extracts from Sclerocarya birrea (A. Rich.) Hochst and its chemical profiling by UPLC-Q-TOF-MS.

Authors:  Tinotenda Shoko; Vinesh J Maharaj; Dashnie Naidoo; Malefa Tselanyane; Rudzani Nthambeleni; Eric Khorombi; Zeno Apostolides
Journal:  BMC Complement Altern Med       Date:  2018-02-07       Impact factor: 3.659
  9 in total

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