| Literature DB >> 11801630 |
Rebecca J Greenwald1, Alexander J McAdam, Diane Van der Woude, Abhay R Satoskar, Arlene H Sharpe.
Abstract
The CD28 family member inducible costimulator protein (ICOS) has an important role in T cell differentiation and Ig class switching. To investigate the role of ICOS in vivo, ICOS-/- mice were infected s.c. with Leishmania mexicana. While wild-type mice developed large, cutaneous lesions, the growth of lesions and tissue histopathology was significantly delayed in ICOS-/- mice. ICOS-/- mice exhibited marked decreases in both Th1 and Th2 cytokine production and profound defects in L. mexicana-specific Ig isotype class switching to IgG1 and IgG2a and reduced total IgE levels. Our findings indicate that ICOS is a key regulator of both Th1 and Th2 responses and has a role in controlling cutaneous L. mexicana infection.Entities:
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Year: 2002 PMID： 11801630 DOI： 10.4049/jimmunol.168.3.991
Source DB: PubMed Journal: J Immunol ISSN： 0022-1767 Impact factor: 5.422