Literature DB >> 11801174

Epigenetics as a first exit problem.

E Aurell1, K Sneppen.   

Abstract

We develop a framework to discuss the stability of epigenetic states as first exit problems in dynamical systems with noise. We consider in particular the stability of the lysogenic state of the lambda prophage. The formalism defines a quantitative measure of robustness of inherited states.

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Year:  2002        PMID： 11801174     DOI： 10.1103/PhysRevLett.88.048101

Source DB:  PubMed          Journal:  Phys Rev Lett        ISSN： 0031-9007            Impact factor:   9.161


  47 in total

1.  Stochastic gene expression as a many-body problem.

Authors:  Masaki Sasai; Peter G Wolynes
Journal:  Proc Natl Acad Sci U S A       Date:  2003-02-26       Impact factor: 11.205

2.  Identifying dynamical bottlenecks of stochastic transitions in biochemical networks.

Authors:  Christopher C Govern; Ming Yang; Arup K Chakraborty
Journal:  Phys Rev Lett       Date:  2012-01-30       Impact factor: 9.161

3.  Why the lysogenic state of phage lambda is so stable: a mathematical modeling approach.

Authors:  Moisés Santillán; Michael C Mackey
Journal:  Biophys J       Date:  2004-01       Impact factor: 4.033

4.  Self-consistent proteomic field theory of stochastic gene switches.

Authors:  Aleksandra M Walczak; Masaki Sasai; Peter G Wolynes
Journal:  Biophys J       Date:  2004-11-12       Impact factor: 4.033

5.  The potential landscape of genetic circuits imposes the arrow of time in stem cell differentiation.

Authors:  Jin Wang; Li Xu; Erkang Wang; Sui Huang
Journal:  Biophys J       Date:  2010-07-07       Impact factor: 4.033

6.  DNA-Binding Kinetics Determines the Mechanism of Noise-Induced Switching in Gene Networks.

Authors:  Margaret J Tse; Brian K Chu; Mahua Roy; Elizabeth L Read
Journal:  Biophys J       Date:  2015-10-20       Impact factor: 4.033

7.  Dichotomous noise models of gene switches.

Authors:  Davit A Potoyan; Peter G Wolynes
Journal:  J Chem Phys       Date:  2015-11-21       Impact factor: 3.488

8.  Absolute rate theories of epigenetic stability.

Authors:  Aleksandra M Walczak; José N Onuchic; Peter G Wolynes
Journal:  Proc Natl Acad Sci U S A       Date:  2005-12-16       Impact factor: 11.205

9.  A quantitative study of lambda-phage SWITCH and its components.

Authors:  Chunbo Lou; Xiaojing Yang; Xili Liu; Bin He; Qi Ouyang
Journal:  Biophys J       Date:  2007-01-26       Impact factor: 4.033

10.  Epigenetic chromatin silencing: bistability and front propagation.

Authors:  Mohammad Sedighi; Anirvan M Sengupta
Journal:  Phys Biol       Date:  2007-11-07       Impact factor: 2.583
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