| Literature DB >> 11800088 |
H Goto1, H Matsuo, S Nakane, H Izumoto, T Fukudome, C Kambara, N Shibuya.
Abstract
Plasmapheresis not only removes humoral factors, but may also modulate cellular immunity. We investigated whether plasmapheresis influenced T helper type-1/T helper type-2 (Th1/Th2) cytokine-producing-cell balance in 3 patients with neuroimmunological disease. The production of interferon-gamma (IFN-gamma), interleukin-2 (IL-2), and IL-4 in the culture supernatant of peripheral blood mononuclear cells stimulated by anti-CD3 and anti-CD28 was assayed. In 2 of 3 patients, plasmapheresis (immunoadsorption or plasma exchange) reduced Th1/Th2 cytokine ratio. The results may suggest that plasmapheresis induces a shift of Th1/Th2 balance in peripheral blood.Entities:
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Year: 2001 PMID： 11800088 DOI： 10.1046/j.1526-0968.2001.00386.x
Source DB: PubMed Journal: Ther Apher ISSN： 1091-6660