| Literature DB >> 11799395 |
Daniel G Miller1, Elizabeth A Rutledge, David W Russell.
Abstract
Adeno-associated virus (AAV) vectors are currently being used in several clinical gene-therapy trials (see the NIH OBA Human Gene Transfer Clinical Trials Database); however, little is known about the chromosomal effects of vector integration. Here we report that integrated vector proviruses are associated with chromosomal deletions and other rearrangements and are frequently located on chromosome 19 (although not at the wildtype AAV integration site).Entities:
Mesh：
Substances：
Year: 2002 PMID： 11799395 DOI： 10.1038/ng824
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330