Literature DB >> 11799246

Regulation of life-span by germ-line stem cells in Caenorhabditis elegans.

Nuno Arantes-Oliveira1, Javier Apfeld, Andrew Dillin, Cynthia Kenyon.   

Abstract

The germ line of the nematode Caenorhabditis elegans influences life-span; when the germ-line precursor cells are removed, life-span is increased dramatically. We find that neither sperm, nor oocytes, nor meiotic precursor cells are responsible for this effect. Rather life-span is influenced by the proliferating germ-line stem cells. These cells, as well as a downstream transcriptional regulator, act in the adult to influence aging, indicating that the aging process remains plastic during adulthood. We propose that the germ-line stem cells affect life-span by influencing the production of, or the response to, a steroid hormone that promotes longevity.

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Year:  2002        PMID： 11799246     DOI： 10.1126/science.1065768

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  201 in total

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5.  Suppression of transcriptional drift extends C. elegans lifespan by postponing the onset of mortality.

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8.  Systemic stress signalling: understanding the cell non-autonomous control of proteostasis.

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9.  Transplantation of young ovaries to old mice increased life span in transplant recipients.

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10.  Distinct activities of the germline and somatic reproductive tissues in the regulation of Caenorhabditis elegans' longevity.

Authors:  Tracy M Yamawaki; Nuno Arantes-Oliveira; Jennifer R Berman; Peichuan Zhang; Cynthia Kenyon
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