B Du1, D Chen, D Liu. 1. Department of Critical Care Medicine, Peking Union Medical College Hospital, Beijing 100730, China.
Abstract
OBJECTIVE: To describe the clinical properties of multiple organ dysfunction syndromB (MODS) with sepsis-related organ failure assessment (SOFA). METHODS: A total of 366 MODS patients admitted to the 5 participating ICUs from 1990 to 1996 were included in this study. SOFA score and demographic data were retrospectively evaluated. RESULTS: Total maximum SOFA score, delta SOFA and admission total SOFA score exhibited a good correlation with hospital mortality rate, with the area under the ROC curve of 0.819, 0.750 and 0.616, respectively. The SOFA score for patients without organ failure was 3.7 +/- 1.2, with a mortality rate of 21.7%, and the SOFA score for patients with failure of all 6 organs was 20.2 +/- 1.4, with a mortality rate of 77.8%. A maximum score was firstly reached for respiratory system (1.41 days after admission), and last for cardiovascular system (4.89 days). Logistic regression model revealed that the central nervous system was associated with the highest relative contribution (odds ratio 1.75) to hospital outcome, followed by renal (OR 1.42), cardiovascular (OR 1.38), coagulation (OR 1.34) and respiratory (OR 1.17) systems. No independent contribution was found for the hepatic score (OR 0.99). CONCLUSION: Total maximum SOFA score and delta SOFA can be used to quantify the progress of MODS during ICU stay.
OBJECTIVE: To describe the clinical properties of multiple organ dysfunction syndromB (MODS) with sepsis-related organ failure assessment (SOFA). METHODS: A total of 366 MODS patients admitted to the 5 participating ICUs from 1990 to 1996 were included in this study. SOFA score and demographic data were retrospectively evaluated. RESULTS: Total maximum SOFA score, delta SOFA and admission total SOFA score exhibited a good correlation with hospital mortality rate, with the area under the ROC curve of 0.819, 0.750 and 0.616, respectively. The SOFA score for patients without organ failure was 3.7 +/- 1.2, with a mortality rate of 21.7%, and the SOFA score for patients with failure of all 6 organs was 20.2 +/- 1.4, with a mortality rate of 77.8%. A maximum score was firstly reached for respiratory system (1.41 days after admission), and last for cardiovascular system (4.89 days). Logistic regression model revealed that the central nervous system was associated with the highest relative contribution (odds ratio 1.75) to hospital outcome, followed by renal (OR 1.42), cardiovascular (OR 1.38), coagulation (OR 1.34) and respiratory (OR 1.17) systems. No independent contribution was found for the hepatic score (OR 0.99). CONCLUSION: Total maximum SOFA score and delta SOFA can be used to quantify the progress of MODS during ICU stay.