Intermittent low dose itraconazole treatment for onychomycosis--long term follow-up.

Eighty-seven patients with toenail onychomycosis were treated with intermittent low-dose itraconazole, 200 mg day(-1) for one week every four weeks; this regimen was repeated six times. A total of 77 patients (88.5%) showed microscopical and cultural cure after 6 months of treatment. A three-year follow-up showed a relapse rate of 6.5% occurring only during the first year after treatment.