| Literature DB >> 11796923 |
Yashusi Adachi1, Shigeru Taketani, Junko Toki, Kazuya Ikebukuro, Kikuya Sugiura, Haruki Oyaizu, Ryoji Yasumizu, Minoru Tomita, Hiroyuki Kaneda, Yasuo Amoh, Tomoki Ito, Mitsuhiko Okigaki, Muneo Inaba, Susumu Ikehara.
Abstract
Here, we report that the number of CD11c(+)CD3(-) B220(-) cells increases in autoimmune-prone male (NZW x BXSB)F1 (W/BF1) mice with age. The CD11c(+)CD3(-)B220(-) cells from W/BF1 mice show a typical stellate shape and induce the proliferation of T cells. In the CD11c(+)CD3(-)B220(-) cells from W/BF1 mice, CD11b (Mac-1alpha), NK 1.1, and CD95 (Fas) are upregulated in comparison with normal mice, while the expression of CD8alpha, CD117 (c-kit), CD135 (Flk-2/Flt-3), and Sca-1 decreases. There is a significant increase in Flt-3L (FL) mRNA in the bone marrow of W/BF1 mice with age. Moreover, activated hemopoietic cells express high levels of FL. The injection of CD11c(+)CD3(-)B220(-) cells from old W/BF1 mice to young W/BF1 mice transiently induces autoimmune disease (thrombocytopenia). These results suggest that hyperproduction of FL from activated hemopoietic cells induces a dramatic increase in the number of dendritic cells in aged W/BF1 mice, followed by the acceleration of autoimmunity.Entities:
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Year: 2002 PMID： 11796923 DOI： 10.1634/stemcells.20-1-61
Source DB: PubMed Journal: Stem Cells ISSN： 1066-5099 Impact factor: 6.277