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Literature DB >> 11796645

Leishmania major promastigotes inhibit dendritic cell motility in vitro.

Heather Jebbari¹, Andrew J Stagg, Robert N Davidson, Stella C Knight.

Abstract

Using an in vitro transwell migration assay, we have demonstrated that products secreted by Leishmania major promastigotes inhibit the motility of dendritic cells (DC) by up to 93%. Inhibition was dose dependent and reversible. By inhibiting DC migration in vivo, L. major may therefore subvert DC from their potentially protective role during leishmaniasis.

Entities: Disease Species

Mesh：

Substances：

Year: 2002 PMID： 11796645 PMCID： PMC127657 DOI： 10.1128/IAI.70.2.1023-1026.2002

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

22 in total

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11 in total

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Authors: César A Terrazas; Luis I Terrazas; Lorena Gómez-García
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Journal: Parasit Vectors Date: 2011-11-14 Impact factor: 3.876

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Authors: Micely D R Hermida; Priscila G Doria; Angela M P Taguchi; José O Mengel; Washington L C dos-Santos
Journal: BMC Infect Dis Date: 2014-08-20 Impact factor: 3.090

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Authors: Sreenivas Gannavaram; Parna Bhattacharya; Nevien Ismail; Amit Kaul; Rakesh Singh; Hira L Nakhasi
Journal: Front Immunol Date: 2016-05-13 Impact factor: 7.561

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Authors: Esther Caparrós; Diego Serrano; Amaya Puig-Kröger; Lorena Riol; Fátima Lasala; Iñigo Martinez; Fernando Vidal-Vanaclocha; Rafael Delgado; José Luis Rodríguez-Fernández; Luis Rivas; Angel L Corbí; María Colmenares
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9. Immunomodulatory Effects of Four Leishmania infantum Potentially Excreted/Secreted Proteins on Human Dendritic Cells Differentiation and Maturation.

Authors: Wafa Markikou-Ouni; Sima Drini; Narges Bahi-Jaber; Mehdi Chenik; Amel Meddeb-Garnaoui
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Review 10. Leishmania Hijacks Myeloid Cells for Immune Escape.

Authors: María Martínez-López; Manuel Soto; Salvador Iborra; David Sancho
Journal: Front Microbiol Date: 2018-05-07 Impact factor: 5.640