Literature DB >> 11796642

Antigenic specificity of the Mycobacterium leprae homologue of ESAT-6.

John S Spencer1, Maria Angela M Marques, Monica C B S Lima, Ana Paula Junqueira-Kipnis, Bruce C Gregory, Richard W Truman, Patrick J Brennan.   

Abstract

The sequence of the Mycobacterium leprae homologue of ESAT-6 shows only 36% amino acid correspondence to that from Mycobacterium tuberculosis. Anti-M. leprae ESAT-6 polyclonal and monoclonal antibodies and T-cell hybridomas reacted only with the homologous protein and allowed identification of the B- and T-cell epitopes. The protein is expressed in M. leprae and appears in the cell wall fraction. Thus, M. leprae ESAT-6 shows promise as a specific diagnostic agent for leprosy.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 11796642      PMCID： PMC127711          DOI： 10.1128/IAI.70.2.1010-1013.2002

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  29 in total

1.  Elimination of leprosy as a public health problem (update).

Authors: 
Journal:  Wkly Epidemiol Rec       Date:  1998-10-02

2.  Induction of Th1 cytokine responses by mycobacterial antigens in leprosy.

Authors:  H M Dockrell; S K Young; K Britton; P J Brennan; B Rivoire; M F Waters; S B Lucas; F Shahid; M Dojki; T J Chiang; Q Ehsan; K P McAdam; R Hussain
Journal:  Infect Immun       Date:  1996-10       Impact factor: 3.441

3.  Mapping and identification of the major cell wall-associated components of Mycobacterium leprae.

Authors:  M A Marques; S Chitale; P J Brennan; M C Pessolani
Journal:  Infect Immun       Date:  1998-06       Impact factor: 3.441

4.  Key epitopes on the ESAT-6 antigen recognized in mice during the recall of protective immunity to Mycobacterium tuberculosis.

Authors:  L Brandt; T Oettinger; A Holm; A B Andersen; P Andersen
Journal:  J Immunol       Date:  1996-10-15       Impact factor: 5.422

5.  The major native proteins of the leprosy bacillus.

Authors:  S W Hunter; B Rivoire; V Mehra; B R Bloom; P J Brennan
Journal:  J Biol Chem       Date:  1990-08-25       Impact factor: 5.157

6.  Purification and characterization of a low-molecular-mass T-cell antigen secreted by Mycobacterium tuberculosis.

Authors:  A L Sørensen; S Nagai; G Houen; P Andersen; A B Andersen
Journal:  Infect Immun       Date:  1995-05       Impact factor: 3.441

7.  Evidence for occurrence of the ESAT-6 protein in Mycobacterium tuberculosis and virulent Mycobacterium bovis and for its absence in Mycobacterium bovis BCG.

Authors:  M Harboe; T Oettinger; H G Wiker; I Rosenkrands; P Andersen
Journal:  Infect Immun       Date:  1996-01       Impact factor: 3.441

8.  Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.

Authors:  S T Cole; R Brosch; J Parkhill; T Garnier; C Churcher; D Harris; S V Gordon; K Eiglmeier; S Gas; C E Barry; F Tekaia; K Badcock; D Basham; D Brown; T Chillingworth; R Connor; R Davies; K Devlin; T Feltwell; S Gentles; N Hamlin; S Holroyd; T Hornsby; K Jagels; A Krogh; J McLean; S Moule; L Murphy; K Oliver; J Osborne; M A Quail; M A Rajandream; J Rogers; S Rutter; K Seeger; J Skelton; R Squares; S Squares; J E Sulston; K Taylor; S Whitehead; B G Barrell
Journal:  Nature       Date:  1998-06-11       Impact factor: 49.962

9.  Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis.

Authors:  G G Mahairas; P J Sabo; M J Hickey; D C Singh; C K Stover
Journal:  J Bacteriol       Date:  1996-03       Impact factor: 3.490

10.  A major T cell antigen of Mycobacterium leprae is a 10-kD heat-shock cognate protein.

Authors:  V Mehra; B R Bloom; A C Bajardi; C L Grisso; P A Sieling; D Alland; J Convit; X D Fan; S W Hunter; P J Brennan
Journal:  J Exp Med       Date:  1992-01-01       Impact factor: 14.307
View more
  14 in total

1.  Postgenomic approach to identify novel Mycobacterium leprae antigens with potential to improve immunodiagnosis of infection.

Authors:  Annemieke Geluk; Michèl R Klein; Kees L M C Franken; Krista E van Meijgaarden; Brigitte Wieles; Kelly Cristina Pereira; Samira Bührer-Sékula; Paul R Klatser; Patrick J Brennan; John S Spencer; Diana L Williams; Maria C V Pessolani; Elizabeth P Sampaio; Tom H M Ottenhoff
Journal:  Infect Immun       Date:  2005-09       Impact factor: 3.441

2.  Gene expression profile and immunological evaluation of unique hypothetical unknown proteins of Mycobacterium leprae by using quantitative real-time PCR.

Authors:  Hee Jin Kim; Kalyani Prithiviraj; Nathan Groathouse; Patrick J Brennan; John S Spencer
Journal:  Clin Vaccine Immunol       Date:  2012-12-12

3.  T-cell responses to the Mycobacterium tuberculosis-specific antigen ESAT-6 in Brazilian tuberculosis patients.

Authors:  Fernando L L Cardoso; Paulo R Z Antas; Alexandre S Milagres; Annemieke Geluk; Kees L M C Franken; Eliane B Oliveira; Henrique C Teixeira; Susie A Nogueira; Euzenir N Sarno; Paul Klatser; Tom H M Ottenhoff; Elizabeth P Sampaio
Journal:  Infect Immun       Date:  2002-12       Impact factor: 3.441

4.  Identification and characterization of the ESAT-6 homologue of Mycobacterium leprae and T-cell cross-reactivity with Mycobacterium tuberculosis.

Authors:  Annemieke Geluk; Krista E van Meijgaarden; Kees L M C Franken; Yanri W Subronto; Brigitte Wieles; Sandra M Arend; Elizabeth P Sampaio; Tjitske de Boer; William R Faber; Ben Naafs; Tom H M Ottenhoff
Journal:  Infect Immun       Date:  2002-05       Impact factor: 3.441

Review 5.  The continuing challenges of leprosy.

Authors:  D M Scollard; L B Adams; T P Gillis; J L Krahenbuhl; R W Truman; D L Williams
Journal:  Clin Microbiol Rev       Date:  2006-04       Impact factor: 26.132

6.  Mycobacterium tuberculosis EspK Has Active but Distinct Roles in the Secretion of EsxA and EspB.

Authors:  Ze Long Lim; Kylee Drever; Neeraj Dhar; Stewart T Cole; Jeffrey M Chen
Journal:  J Bacteriol       Date:  2022-03-22       Impact factor: 3.476

7.  Gamma interferon responses induced by a panel of recombinant and purified mycobacterial antigens in healthy, non-mycobacterium bovis BCG-vaccinated Malawian young adults.

Authors:  Gillian F Black; Rosemary E Weir; Steven D Chaguluka; David Warndorff; Amelia C Crampin; Lorren Mwaungulu; Lifted Sichali; Sian Floyd; Lyn Bliss; Elizabeth Jarman; Linda Donovan; Peter Andersen; Warwick Britton; Glyn Hewinson; Kris Huygen; Jens Paulsen; Mahavir Singh; Ross Prestidge; Paul E M Fine; Hazel M Dockrell
Journal:  Clin Diagn Lab Immunol       Date:  2003-07

8.  Comparative analysis of B- and T-cell epitopes of Mycobacterium leprae and Mycobacterium tuberculosis culture filtrate protein 10.

Authors:  John S Spencer; Hee Jin Kim; Angela M Marques; Mercedes Gonzalez-Juarerro; Monica C B S Lima; Varalakshmi D Vissa; Richard W Truman; Maria Laura Gennaro; Sang-Nae Cho; Stewart T Cole; Patrick J Brennan
Journal:  Infect Immun       Date:  2004-06       Impact factor: 3.441

9.  Rational combination of peptides derived from different Mycobacterium leprae proteins improves sensitivity for immunodiagnosis of M. leprae infection.

Authors:  Annemieke Geluk; Jolien van der Ploeg; Rose O B Teles; Kees L M C Franken; Corine Prins; Jan Wouter Drijfhout; Euzenir N Sarno; Elizabeth P Sampaio; Tom H M Ottenhoff
Journal:  Clin Vaccine Immunol       Date:  2008-01-16

10.  An analysis of the epitope knowledge related to Mycobacteria.

Authors:  Martin J Blythe; Qing Zhang; Kerrie Vaughan; Romulo de Castro; Nima Salimi; Huynh-Hoa Bui; David M Lewinsohn; Joel D Ernst; Bjoern Peters; Alessandro Sette
Journal:  Immunome Res       Date:  2007-12-14
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.